DAP12 and CD11b contribute to the microglial-induced death of dopaminergic neurons in vitro but not in vivo in the MPTP mouse model of Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by a loss of dopaminergic neurons (DN) in the substantia nigra (SN). Several lines of evidence suggest that apoptotic cell death of DN is driven in part by non-cell autonomous mechanisms orchestrated by microglial cel...

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Detalles Bibliográficos
Autores principales: Kinugawa, Kiyoka, Monnet, Yann, Béchade, Catherine, Alvarez-Fischer, Daniel, Hirsch, Etienne C, Bessis, Alain, Hunot, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720270/
https://www.ncbi.nlm.nih.gov/pubmed/23844828
http://dx.doi.org/10.1186/1742-2094-10-82

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