Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanisms

Constitutively activated signaling molecules are often the primary drivers of malignancy, and are favored targets for therapeutic intervention. However, the effectiveness of targeted inhibition of cell signaling can be blunted by compensatory signaling which generates adaptive resistance mechanisms...

Descripción completa

Detalles Bibliográficos
Autores principales: Axelrod, Mark, Gordon, Vicki L., Conaway, Mark, Tarcsafalvi, Adel, Neitzke, Daniel J., Gioeli, Daniel, Weber, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720609/
https://www.ncbi.nlm.nih.gov/pubmed/23599172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720609/
https://www.ncbi.nlm.nih.gov/pubmed/23599172

Ejemplares similares