Challenges in Using Cultured Primary Rodent Hepatocytes or Cell Lines to Study Hepatic HDL Receptor SR-BI Regulation by Its Cytoplasmic Adaptor PDZK1

BACKGROUND: PDZK1 is a four PDZ-domain containing cytoplasmic protein that binds to a variety of membrane proteins via their C-termini and can influence the abundance, localization and/or function of its target proteins. One of these targets in hepatocytes in vivo is the HDL receptor SR-BI. Normal h...

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Detalles Bibliográficos
Autores principales: Tsukamoto, Kosuke, Buck, Lorenna, Inman, Walker, Griffith, Linda, Kocher, Olivier, Krieger, Monty
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720616/
https://www.ncbi.nlm.nih.gov/pubmed/23936087
http://dx.doi.org/10.1371/journal.pone.0069725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720616/
https://www.ncbi.nlm.nih.gov/pubmed/23936087
http://dx.doi.org/10.1371/journal.pone.0069725

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