A Mouse Model of Familial ALS Has Increased CNS Levels of Endogenous Ubiquinol(9/10) and Does Not Benefit from Exogenous Administration of Ubiquinol(10)

Oxidative stress and mitochondrial impairment are the main pathogenic mechanisms of Amyotrophic Lateral Sclerosis (ALS), a severe neurodegenerative disease still lacking of effective therapy. Recently, the coenzyme-Q (CoQ) complex, a key component of mitochondrial function and redox-state modulator,...

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Detalles Bibliográficos
Autores principales: Lucchetti, Jacopo, Marino, Marianna, Papa, Simonetta, Tortarolo, Massimo, Guiso, Giovanna, Pozzi, Silvia, Bonetto, Valentina, Caccia, Silvio, Beghi, Ettore, Bendotti, Caterina, Gobbi, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720666/
https://www.ncbi.nlm.nih.gov/pubmed/23936040
http://dx.doi.org/10.1371/journal.pone.0069540

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