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A Serine-Substituted P450 Catalyzes Highly Efficient Carbene Transfer to Olefins In Vivo

Genetically encoded catalysts for non-natural chemical reactions will open new routes to sustainable production of chemicals. We designed a unique serine-heme ligated cytochrome “P411” that catalyzes efficient and selective carbene transfers from diazoesters to olefins in intact Escherichia coli cel...

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Detalles Bibliográficos
Autores principales:	Coelho, Pedro S., Wang, Z. Jane, Ener, Maraia E., Baril, Stefanie A., Kannan, Arvind A., Arnold, Frances H., Brustad, Eric M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720782/ https://www.ncbi.nlm.nih.gov/pubmed/23792734 http://dx.doi.org/10.1038/nchembio.1278

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