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Sex and Breed-Dependent Organ Development and Metabolic Responses in Foetuses from Lean and Obese/Leptin Resistant Swine

The present study aimed to determine the effects of breed and sex on growth patterns and metabolic features of advanced-pregnancy foetuses exposed to the same environmental conditions. Thus, at Day 62 of pregnancy, swine foetuses from an obese breed with leptin resistance (Iberian breed) were compar...

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Autores principales: Torres-Rovira, Laura, Tarrade, Anne, Astiz, Susana, Mourier, Eve, Perez-Solana, Mariluz, de la Cruz, Paloma, Gomez-Fidalgo, Ernesto, Sanchez-Sanchez, Raul, Chavatte-Palmer, Pascale, Gonzalez-Bulnes, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720837/
https://www.ncbi.nlm.nih.gov/pubmed/23935823
http://dx.doi.org/10.1371/journal.pone.0066728
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author Torres-Rovira, Laura
Tarrade, Anne
Astiz, Susana
Mourier, Eve
Perez-Solana, Mariluz
de la Cruz, Paloma
Gomez-Fidalgo, Ernesto
Sanchez-Sanchez, Raul
Chavatte-Palmer, Pascale
Gonzalez-Bulnes, Antonio
author_facet Torres-Rovira, Laura
Tarrade, Anne
Astiz, Susana
Mourier, Eve
Perez-Solana, Mariluz
de la Cruz, Paloma
Gomez-Fidalgo, Ernesto
Sanchez-Sanchez, Raul
Chavatte-Palmer, Pascale
Gonzalez-Bulnes, Antonio
author_sort Torres-Rovira, Laura
collection PubMed
description The present study aimed to determine the effects of breed and sex on growth patterns and metabolic features of advanced-pregnancy foetuses exposed to the same environmental conditions. Thus, at Day 62 of pregnancy, swine foetuses from an obese breed with leptin resistance (Iberian breed) were compared to lean crossbred foetuses (25% Large White ×25% Landrace ×50% Pietrain). There were differential developmental patterns in foetuses with leptin resistance, mainly a higher relative weight of the brain resembling “brain-sparing effect”. Prioritization of brain growth may be protective for the adequate growth and postnatal survival of the Iberian individuals, an ancient breed reared in extensive semi-feral conditions for centuries. There were also clear sex-related differences in foetal development and metabolism in the Iberian breed. Female Iberian foetuses were similar in size and weight to male littermates but had a significantly higher relative liver to body weight ratio resembling “liver-sparing effect” and a trend for a higher relative intestine to body ratio. Moreover, the availability of triglycerides, cholesterol and IL-6 in female Iberian foetuses was similar to that of lean crossbred foetuses. Overall, these features may favour a better postnatal survival and development of females, the sex more critical for the species survival. These findings set the basis for future translational studies aimed at increasing the knowledge on the interaction between genetic and environmental factors in the early programming of the adult phenotype.
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spelling pubmed-37208372013-08-09 Sex and Breed-Dependent Organ Development and Metabolic Responses in Foetuses from Lean and Obese/Leptin Resistant Swine Torres-Rovira, Laura Tarrade, Anne Astiz, Susana Mourier, Eve Perez-Solana, Mariluz de la Cruz, Paloma Gomez-Fidalgo, Ernesto Sanchez-Sanchez, Raul Chavatte-Palmer, Pascale Gonzalez-Bulnes, Antonio PLoS One Research Article The present study aimed to determine the effects of breed and sex on growth patterns and metabolic features of advanced-pregnancy foetuses exposed to the same environmental conditions. Thus, at Day 62 of pregnancy, swine foetuses from an obese breed with leptin resistance (Iberian breed) were compared to lean crossbred foetuses (25% Large White ×25% Landrace ×50% Pietrain). There were differential developmental patterns in foetuses with leptin resistance, mainly a higher relative weight of the brain resembling “brain-sparing effect”. Prioritization of brain growth may be protective for the adequate growth and postnatal survival of the Iberian individuals, an ancient breed reared in extensive semi-feral conditions for centuries. There were also clear sex-related differences in foetal development and metabolism in the Iberian breed. Female Iberian foetuses were similar in size and weight to male littermates but had a significantly higher relative liver to body weight ratio resembling “liver-sparing effect” and a trend for a higher relative intestine to body ratio. Moreover, the availability of triglycerides, cholesterol and IL-6 in female Iberian foetuses was similar to that of lean crossbred foetuses. Overall, these features may favour a better postnatal survival and development of females, the sex more critical for the species survival. These findings set the basis for future translational studies aimed at increasing the knowledge on the interaction between genetic and environmental factors in the early programming of the adult phenotype. Public Library of Science 2013-07-23 /pmc/articles/PMC3720837/ /pubmed/23935823 http://dx.doi.org/10.1371/journal.pone.0066728 Text en © 2013 Torres-Rovira et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Torres-Rovira, Laura
Tarrade, Anne
Astiz, Susana
Mourier, Eve
Perez-Solana, Mariluz
de la Cruz, Paloma
Gomez-Fidalgo, Ernesto
Sanchez-Sanchez, Raul
Chavatte-Palmer, Pascale
Gonzalez-Bulnes, Antonio
Sex and Breed-Dependent Organ Development and Metabolic Responses in Foetuses from Lean and Obese/Leptin Resistant Swine
title Sex and Breed-Dependent Organ Development and Metabolic Responses in Foetuses from Lean and Obese/Leptin Resistant Swine
title_full Sex and Breed-Dependent Organ Development and Metabolic Responses in Foetuses from Lean and Obese/Leptin Resistant Swine
title_fullStr Sex and Breed-Dependent Organ Development and Metabolic Responses in Foetuses from Lean and Obese/Leptin Resistant Swine
title_full_unstemmed Sex and Breed-Dependent Organ Development and Metabolic Responses in Foetuses from Lean and Obese/Leptin Resistant Swine
title_short Sex and Breed-Dependent Organ Development and Metabolic Responses in Foetuses from Lean and Obese/Leptin Resistant Swine
title_sort sex and breed-dependent organ development and metabolic responses in foetuses from lean and obese/leptin resistant swine
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720837/
https://www.ncbi.nlm.nih.gov/pubmed/23935823
http://dx.doi.org/10.1371/journal.pone.0066728
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