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High Glucose Promotes Aβ Production by Inhibiting APP Degradation
Abnormal deposition of neuriticplaques is the uniqueneuropathological hallmark of Alzheimer’s disease (AD).Amyloid β protein (Aβ), the major component of plaques, is generated from sequential cleavage of amyloidβ precursor protein (APP) by β-secretase and γ-secretase complex. Patients with diabetes...
Autores principales: | Yang, Yi, Wu, Yili, Zhang, Shuting, Song, Weihong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720941/ https://www.ncbi.nlm.nih.gov/pubmed/23894546 http://dx.doi.org/10.1371/journal.pone.0069824 |
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