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Migraine in gulf war illness and chronic fatigue syndrome: prevalence, potential mechanisms, and evaluation

Objective: To assess the prevalence of headache subtypes in Gulf War Illness (GWI) and Chronic Fatigue Syndrome (CFS) compared to controls. Background: Approximately, 25% of the military personnel who served in the 1990–1991 Persian Gulf War have developed GWI. Symptoms of GWI and CFS have considera...

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Autores principales: Rayhan, Rakib U., Ravindran, Murugan K., Baraniuk, James N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721020/
https://www.ncbi.nlm.nih.gov/pubmed/23898301
http://dx.doi.org/10.3389/fphys.2013.00181
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author Rayhan, Rakib U.
Ravindran, Murugan K.
Baraniuk, James N.
author_facet Rayhan, Rakib U.
Ravindran, Murugan K.
Baraniuk, James N.
author_sort Rayhan, Rakib U.
collection PubMed
description Objective: To assess the prevalence of headache subtypes in Gulf War Illness (GWI) and Chronic Fatigue Syndrome (CFS) compared to controls. Background: Approximately, 25% of the military personnel who served in the 1990–1991 Persian Gulf War have developed GWI. Symptoms of GWI and CFS have considerable overlap, including headache complaints. Migraines are reported in CFS. The type and prevalence of headaches in GWI have not been adequately assessed. Methods: 50 GWI, 39 CFS and 45 controls had structured headache evaluations based on the 2004 International Headache Society criteria. All subjects had history and physical examinations, fatigue and symptom related questionnaires, measurements of systemic hyperalgesia (dolorimetry), and assessments for exclusionary conditions. Results: Migraines were detected in 64% of GWI (odds ratio = 11.6 [4.1–32.5]) (mean [±95% CI]) and 82% of CFS subjects (odds ratio = 22.5 [7.8–64.8]) compared to only 13% of controls. There was a predominance of females in the CFS compared to GWI and controls. However, migraine status was independent of gender in GWI and CFS groups (x(2) = 2.7; P = 0.101). Measures of fatigue, pain, and other ancillary criteria were comparable between GWI and CFS subjects with and without headache. Conclusion: The high prevalence of migraine in CFS was confirmed and extended to GWI subjects. GWI and CFS may share dysfunctional central pathophysiological pathways that contribute to migraine and subjective symptoms. The high migraine prevalence warrants the inclusion of a structured headache evaluation in GWI and CFS subjects, and treatment when present.
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spelling pubmed-37210202013-07-29 Migraine in gulf war illness and chronic fatigue syndrome: prevalence, potential mechanisms, and evaluation Rayhan, Rakib U. Ravindran, Murugan K. Baraniuk, James N. Front Physiol Physiology Objective: To assess the prevalence of headache subtypes in Gulf War Illness (GWI) and Chronic Fatigue Syndrome (CFS) compared to controls. Background: Approximately, 25% of the military personnel who served in the 1990–1991 Persian Gulf War have developed GWI. Symptoms of GWI and CFS have considerable overlap, including headache complaints. Migraines are reported in CFS. The type and prevalence of headaches in GWI have not been adequately assessed. Methods: 50 GWI, 39 CFS and 45 controls had structured headache evaluations based on the 2004 International Headache Society criteria. All subjects had history and physical examinations, fatigue and symptom related questionnaires, measurements of systemic hyperalgesia (dolorimetry), and assessments for exclusionary conditions. Results: Migraines were detected in 64% of GWI (odds ratio = 11.6 [4.1–32.5]) (mean [±95% CI]) and 82% of CFS subjects (odds ratio = 22.5 [7.8–64.8]) compared to only 13% of controls. There was a predominance of females in the CFS compared to GWI and controls. However, migraine status was independent of gender in GWI and CFS groups (x(2) = 2.7; P = 0.101). Measures of fatigue, pain, and other ancillary criteria were comparable between GWI and CFS subjects with and without headache. Conclusion: The high prevalence of migraine in CFS was confirmed and extended to GWI subjects. GWI and CFS may share dysfunctional central pathophysiological pathways that contribute to migraine and subjective symptoms. The high migraine prevalence warrants the inclusion of a structured headache evaluation in GWI and CFS subjects, and treatment when present. Frontiers Media S.A. 2013-07-24 /pmc/articles/PMC3721020/ /pubmed/23898301 http://dx.doi.org/10.3389/fphys.2013.00181 Text en Copyright © 2013 Rayhan, Ravindran and Baraniuk. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Physiology
Rayhan, Rakib U.
Ravindran, Murugan K.
Baraniuk, James N.
Migraine in gulf war illness and chronic fatigue syndrome: prevalence, potential mechanisms, and evaluation
title Migraine in gulf war illness and chronic fatigue syndrome: prevalence, potential mechanisms, and evaluation
title_full Migraine in gulf war illness and chronic fatigue syndrome: prevalence, potential mechanisms, and evaluation
title_fullStr Migraine in gulf war illness and chronic fatigue syndrome: prevalence, potential mechanisms, and evaluation
title_full_unstemmed Migraine in gulf war illness and chronic fatigue syndrome: prevalence, potential mechanisms, and evaluation
title_short Migraine in gulf war illness and chronic fatigue syndrome: prevalence, potential mechanisms, and evaluation
title_sort migraine in gulf war illness and chronic fatigue syndrome: prevalence, potential mechanisms, and evaluation
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721020/
https://www.ncbi.nlm.nih.gov/pubmed/23898301
http://dx.doi.org/10.3389/fphys.2013.00181
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