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Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis
Three new cembrane-type diterpenoids, flexibilins A–C (1–3), along with a known cembrane, (−)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of cembranes 1–4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistr...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721218/ https://www.ncbi.nlm.nih.gov/pubmed/23752355 http://dx.doi.org/10.3390/md11061999 |
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| author | Hu, Li-Chung Su, Jui-Hsin Chiang, Michael Yen-Nan Lu, Mei-Chin Hwang, Tsong-Long Chen, Yung-Husan Hu, Wan-Ping Lin, Nai-Cheng Wang, Wei-Hsien Fang, Lee-Shing Kuo, Yueh-Hsiung Sung, Ping-Jyun |
| author_facet | Hu, Li-Chung Su, Jui-Hsin Chiang, Michael Yen-Nan Lu, Mei-Chin Hwang, Tsong-Long Chen, Yung-Husan Hu, Wan-Ping Lin, Nai-Cheng Wang, Wei-Hsien Fang, Lee-Shing Kuo, Yueh-Hsiung Sung, Ping-Jyun |
| author_sort | Hu, Li-Chung |
| collection | PubMed |
| description | Three new cembrane-type diterpenoids, flexibilins A–C (1–3), along with a known cembrane, (−)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of cembranes 1–4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils. |
| format | Online Article Text |
| id | pubmed-3721218 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-37212182013-07-24 Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis Hu, Li-Chung Su, Jui-Hsin Chiang, Michael Yen-Nan Lu, Mei-Chin Hwang, Tsong-Long Chen, Yung-Husan Hu, Wan-Ping Lin, Nai-Cheng Wang, Wei-Hsien Fang, Lee-Shing Kuo, Yueh-Hsiung Sung, Ping-Jyun Mar Drugs Article Three new cembrane-type diterpenoids, flexibilins A–C (1–3), along with a known cembrane, (−)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of cembranes 1–4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils. MDPI 2013-06-10 /pmc/articles/PMC3721218/ /pubmed/23752355 http://dx.doi.org/10.3390/md11061999 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| spellingShingle | Article Hu, Li-Chung Su, Jui-Hsin Chiang, Michael Yen-Nan Lu, Mei-Chin Hwang, Tsong-Long Chen, Yung-Husan Hu, Wan-Ping Lin, Nai-Cheng Wang, Wei-Hsien Fang, Lee-Shing Kuo, Yueh-Hsiung Sung, Ping-Jyun Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis |
| title | Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis |
| title_full | Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis |
| title_fullStr | Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis |
| title_full_unstemmed | Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis |
| title_short | Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis |
| title_sort | flexibilins a–c, new cembrane-type diterpenoids from the formosan soft coral, sinularia flexibilis |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721218/ https://www.ncbi.nlm.nih.gov/pubmed/23752355 http://dx.doi.org/10.3390/md11061999 |
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