Cembrane Derivatives from the Soft Corals, Sinularia gaweli and Sinularia flexibilis

A new norcembranoidal diterpene, 1-epi-sinulanorcembranolide A (1), and a new cembranoidal diterpene, flexibilin D (2), were isolated from the soft corals, Sinularia gaweli and Sinularia flexibilis, respectively. The structures of new metabolites 1 and 2 were elucidated by spectroscopic methods, and...

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Detalles Bibliográficos
Autores principales: Hu, Li-Chung, Yen, Wei-Hsuan, Su, Jui-Hsin, Chiang, Michael Yen-Nan, Wen, Zhi-Hong, Chen, Wu-Fu, Lu, Ting-Jang, Chang, Yu-Wei, Chen, Yung-Husan, Wang, Wei-Hsien, Wu, Yang-Chang, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721226/
https://www.ncbi.nlm.nih.gov/pubmed/23774887
http://dx.doi.org/10.3390/md11062154
Descripción
Sumario:A new norcembranoidal diterpene, 1-epi-sinulanorcembranolide A (1), and a new cembranoidal diterpene, flexibilin D (2), were isolated from the soft corals, Sinularia gaweli and Sinularia flexibilis, respectively. The structures of new metabolites 1 and 2 were elucidated by spectroscopic methods, and compound 2 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. In addition, S. flexibilis yielded a known cembrane, 5-dehydrosinulariolide (3); the structure, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis.

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