Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus

Two new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and l-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, w...

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Autores principales: Wang, Ming-Hui, Li, Xiao-Ming, Li, Chun-Shun, Ji, Nai-Yun, Wang, Bin-Gui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721231/
https://www.ncbi.nlm.nih.gov/pubmed/23792827
http://dx.doi.org/10.3390/md11062230
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author Wang, Ming-Hui
Li, Xiao-Ming
Li, Chun-Shun
Ji, Nai-Yun
Wang, Bin-Gui
author_facet Wang, Ming-Hui
Li, Xiao-Ming
Li, Chun-Shun
Ji, Nai-Yun
Wang, Bin-Gui
author_sort Wang, Ming-Hui
collection PubMed
description Two new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and l-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addition, six known metabolites (5–10) were also identified. Their structures were elucidated by analysis of the NMR and mass spectroscopic data. The absolute configuration of compound 1 was determined by experimental and calculated ECD spectra. Compound 2 displayed potent brine shrimp (Artemia salina) lethality with LD(50) 11.2 μM.
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spelling pubmed-37212312013-07-24 Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus Wang, Ming-Hui Li, Xiao-Ming Li, Chun-Shun Ji, Nai-Yun Wang, Bin-Gui Mar Drugs Article Two new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and l-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addition, six known metabolites (5–10) were also identified. Their structures were elucidated by analysis of the NMR and mass spectroscopic data. The absolute configuration of compound 1 was determined by experimental and calculated ECD spectra. Compound 2 displayed potent brine shrimp (Artemia salina) lethality with LD(50) 11.2 μM. MDPI 2013-06-21 /pmc/articles/PMC3721231/ /pubmed/23792827 http://dx.doi.org/10.3390/md11062230 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wang, Ming-Hui
Li, Xiao-Ming
Li, Chun-Shun
Ji, Nai-Yun
Wang, Bin-Gui
Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus
title Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus
title_full Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus
title_fullStr Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus
title_full_unstemmed Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus
title_short Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus
title_sort secondary metabolites from penicillium pinophilum sd-272, a marine sediment-derived fungus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721231/
https://www.ncbi.nlm.nih.gov/pubmed/23792827
http://dx.doi.org/10.3390/md11062230
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