Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer

BACKGROUND: Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated. METHODS: We utilised ectopic PRRX1-expressing cell lines to analyse the fun...

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Autores principales: Takahashi, Y, Sawada, G, Kurashige, J, Uchi, R, Matsumura, T, Ueo, H, Takano, Y, Akiyoshi, S, Eguchi, H, Sudo, T, Sugimachi, K, Doki, Y, Mori, M, Mimori, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721401/
https://www.ncbi.nlm.nih.gov/pubmed/23807160
http://dx.doi.org/10.1038/bjc.2013.339
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author Takahashi, Y
Sawada, G
Kurashige, J
Uchi, R
Matsumura, T
Ueo, H
Takano, Y
Akiyoshi, S
Eguchi, H
Sudo, T
Sugimachi, K
Doki, Y
Mori, M
Mimori, K
author_facet Takahashi, Y
Sawada, G
Kurashige, J
Uchi, R
Matsumura, T
Ueo, H
Takano, Y
Akiyoshi, S
Eguchi, H
Sudo, T
Sugimachi, K
Doki, Y
Mori, M
Mimori, K
author_sort Takahashi, Y
collection PubMed
description BACKGROUND: Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated. METHODS: We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC. The clinical significance of PRRX1 was also examined on three independent CRC case sets. RESULTS: PRRX1 induced EMT and the stem-like phenotype in CRC cells. In contrast to studies of breast cancer, abundant expression of PRRX1 was significantly associated with metastasis and poor prognosis in CRC. CONCLUSION: PRRX1 is an indicator of metastasis and poor prognosis in CRC cases. Further investigation is required to uncover the signalling network regulating PRRX1.
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spelling pubmed-37214012014-07-23 Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer Takahashi, Y Sawada, G Kurashige, J Uchi, R Matsumura, T Ueo, H Takano, Y Akiyoshi, S Eguchi, H Sudo, T Sugimachi, K Doki, Y Mori, M Mimori, K Br J Cancer Short Communication BACKGROUND: Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated. METHODS: We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC. The clinical significance of PRRX1 was also examined on three independent CRC case sets. RESULTS: PRRX1 induced EMT and the stem-like phenotype in CRC cells. In contrast to studies of breast cancer, abundant expression of PRRX1 was significantly associated with metastasis and poor prognosis in CRC. CONCLUSION: PRRX1 is an indicator of metastasis and poor prognosis in CRC cases. Further investigation is required to uncover the signalling network regulating PRRX1. Nature Publishing Group 2013-07-23 2013-06-27 /pmc/articles/PMC3721401/ /pubmed/23807160 http://dx.doi.org/10.1038/bjc.2013.339 Text en Copyright © 2013 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Short Communication
Takahashi, Y
Sawada, G
Kurashige, J
Uchi, R
Matsumura, T
Ueo, H
Takano, Y
Akiyoshi, S
Eguchi, H
Sudo, T
Sugimachi, K
Doki, Y
Mori, M
Mimori, K
Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer
title Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer
title_full Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer
title_fullStr Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer
title_full_unstemmed Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer
title_short Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer
title_sort paired related homoeobox 1, a new emt inducer, is involved in metastasis and poor prognosis in colorectal cancer
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721401/
https://www.ncbi.nlm.nih.gov/pubmed/23807160
http://dx.doi.org/10.1038/bjc.2013.339
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