Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78

BACKGROUND: Glucose regulated protein 78 (GRP78) functions as a sensor of endoplasmic reticulum (ER) stress. The aim of this study was to test the hypothesis that molecules that bind to GRP78 induce the unfolded protein response (UPR) and enhance cell death in combination with ER stress inducers. ME...

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Detalles Bibliográficos
Autores principales: Martin, S, Lamb, H K, Brady, C, Lefkove, B, Bonner, M Y, Thompson, P, Lovat, P E, Arbiser, J L, Hawkins, A R, Redfern, C P F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721410/
https://www.ncbi.nlm.nih.gov/pubmed/23807168
http://dx.doi.org/10.1038/bjc.2013.325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721410/
https://www.ncbi.nlm.nih.gov/pubmed/23807168
http://dx.doi.org/10.1038/bjc.2013.325

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