Balancing the fat: lipid droplets and human disease

Lipid droplets (LDs) are dynamic, cytosolic lipid-storage organelles found in nearly all cell types. Too many or too few LDs during excess or deficient fat storage lead to many different human diseases. Recent insights into LD biology and LD protein functions shed new light on mechanisms underlying...

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Detalles Bibliográficos
Autores principales: Krahmer, Natalie, Farese, Robert V, Walther, Tobias C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721468/
https://www.ncbi.nlm.nih.gov/pubmed/23740690
http://dx.doi.org/10.1002/emmm.201100671
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author Krahmer, Natalie
Farese, Robert V
Walther, Tobias C
author_facet Krahmer, Natalie
Farese, Robert V
Walther, Tobias C
author_sort Krahmer, Natalie
collection PubMed
description Lipid droplets (LDs) are dynamic, cytosolic lipid-storage organelles found in nearly all cell types. Too many or too few LDs during excess or deficient fat storage lead to many different human diseases. Recent insights into LD biology and LD protein functions shed new light on mechanisms underlying those metabolic pathologies. These findings will likely provide opportunities for treatment of diseases associated with too much or too little fat.
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spelling pubmed-37214682013-07-25 Balancing the fat: lipid droplets and human disease Krahmer, Natalie Farese, Robert V Walther, Tobias C EMBO Mol Med Review Lipid droplets (LDs) are dynamic, cytosolic lipid-storage organelles found in nearly all cell types. Too many or too few LDs during excess or deficient fat storage lead to many different human diseases. Recent insights into LD biology and LD protein functions shed new light on mechanisms underlying those metabolic pathologies. These findings will likely provide opportunities for treatment of diseases associated with too much or too little fat. Blackwell Publishing Ltd 2013-07 2013-06-06 /pmc/articles/PMC3721468/ /pubmed/23740690 http://dx.doi.org/10.1002/emmm.201100671 Text en © 2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Review
Krahmer, Natalie
Farese, Robert V
Walther, Tobias C
Balancing the fat: lipid droplets and human disease
title Balancing the fat: lipid droplets and human disease
title_full Balancing the fat: lipid droplets and human disease
title_fullStr Balancing the fat: lipid droplets and human disease
title_full_unstemmed Balancing the fat: lipid droplets and human disease
title_short Balancing the fat: lipid droplets and human disease
title_sort balancing the fat: lipid droplets and human disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721468/
https://www.ncbi.nlm.nih.gov/pubmed/23740690
http://dx.doi.org/10.1002/emmm.201100671
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