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Association between C-reactive protein and coronary calcium score in coronary artery disease

BACKGROUND: Both high-sensitivity C-reactive protein (hs-CRP) and spiral computed tomography coronary artery calcium score (CCS) are valid markers of cardiovascular risk. It is unknown whether hs-CRP is a marker of atherosclerotic burden or if it reflects a process leading to acute coronary events....

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Detalles Bibliográficos
Autores principales: Hosseinsabet, Ali, Mohebbi, Ahmad, Almasi, Alireza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Clinics Cardive Publishing 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721600/
https://www.ncbi.nlm.nih.gov/pubmed/19421644
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author Hosseinsabet, Ali
Mohebbi, Ahmad
Almasi, Alireza
author_facet Hosseinsabet, Ali
Mohebbi, Ahmad
Almasi, Alireza
author_sort Hosseinsabet, Ali
collection PubMed
description BACKGROUND: Both high-sensitivity C-reactive protein (hs-CRP) and spiral computed tomography coronary artery calcium score (CCS) are valid markers of cardiovascular risk. It is unknown whether hs-CRP is a marker of atherosclerotic burden or if it reflects a process leading to acute coronary events. METHODS AND RESULTS: We studied the association between hs-CRP and CCS in 143 patients who were candidates for coronary artery bypass grafting (CABG). In our cross-sectional study, we found no significant association between hs-CRP and the CCS in bivariant (p = 0.162) and multivariant (p = 0.062) analyses. However, in patients who did not use statins, this association was significant and positive in the bivariant analysis (p = 0.001), but in the multivariant analysis it was negative and significant (p = 0.008). CONCLUSION: High-sensitivity CRP was not correlated with CCS. The relationship between CRP and clinical events might not be related to atherosclerotic burden. Measures of inflammation, such as hs-CRP, and indices of atherosclerosis, such as CCS, are likely to provide distinct information regarding cardiovascular risk.
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spelling pubmed-37216002013-08-07 Association between C-reactive protein and coronary calcium score in coronary artery disease Hosseinsabet, Ali Mohebbi, Ahmad Almasi, Alireza Cardiovasc J Afr Cardiovascular Topics BACKGROUND: Both high-sensitivity C-reactive protein (hs-CRP) and spiral computed tomography coronary artery calcium score (CCS) are valid markers of cardiovascular risk. It is unknown whether hs-CRP is a marker of atherosclerotic burden or if it reflects a process leading to acute coronary events. METHODS AND RESULTS: We studied the association between hs-CRP and CCS in 143 patients who were candidates for coronary artery bypass grafting (CABG). In our cross-sectional study, we found no significant association between hs-CRP and the CCS in bivariant (p = 0.162) and multivariant (p = 0.062) analyses. However, in patients who did not use statins, this association was significant and positive in the bivariant analysis (p = 0.001), but in the multivariant analysis it was negative and significant (p = 0.008). CONCLUSION: High-sensitivity CRP was not correlated with CCS. The relationship between CRP and clinical events might not be related to atherosclerotic burden. Measures of inflammation, such as hs-CRP, and indices of atherosclerosis, such as CCS, are likely to provide distinct information regarding cardiovascular risk. Clinics Cardive Publishing 2009-04 /pmc/articles/PMC3721600/ /pubmed/19421644 Text en Copyright © 2010 Clinics Cardive Publishing http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cardiovascular Topics
Hosseinsabet, Ali
Mohebbi, Ahmad
Almasi, Alireza
Association between C-reactive protein and coronary calcium score in coronary artery disease
title Association between C-reactive protein and coronary calcium score in coronary artery disease
title_full Association between C-reactive protein and coronary calcium score in coronary artery disease
title_fullStr Association between C-reactive protein and coronary calcium score in coronary artery disease
title_full_unstemmed Association between C-reactive protein and coronary calcium score in coronary artery disease
title_short Association between C-reactive protein and coronary calcium score in coronary artery disease
title_sort association between c-reactive protein and coronary calcium score in coronary artery disease
topic Cardiovascular Topics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721600/
https://www.ncbi.nlm.nih.gov/pubmed/19421644
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