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Association between C-reactive protein and coronary calcium score in coronary artery disease
BACKGROUND: Both high-sensitivity C-reactive protein (hs-CRP) and spiral computed tomography coronary artery calcium score (CCS) are valid markers of cardiovascular risk. It is unknown whether hs-CRP is a marker of atherosclerotic burden or if it reflects a process leading to acute coronary events....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Clinics Cardive Publishing
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721600/ https://www.ncbi.nlm.nih.gov/pubmed/19421644 |
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author | Hosseinsabet, Ali Mohebbi, Ahmad Almasi, Alireza |
author_facet | Hosseinsabet, Ali Mohebbi, Ahmad Almasi, Alireza |
author_sort | Hosseinsabet, Ali |
collection | PubMed |
description | BACKGROUND: Both high-sensitivity C-reactive protein (hs-CRP) and spiral computed tomography coronary artery calcium score (CCS) are valid markers of cardiovascular risk. It is unknown whether hs-CRP is a marker of atherosclerotic burden or if it reflects a process leading to acute coronary events. METHODS AND RESULTS: We studied the association between hs-CRP and CCS in 143 patients who were candidates for coronary artery bypass grafting (CABG). In our cross-sectional study, we found no significant association between hs-CRP and the CCS in bivariant (p = 0.162) and multivariant (p = 0.062) analyses. However, in patients who did not use statins, this association was significant and positive in the bivariant analysis (p = 0.001), but in the multivariant analysis it was negative and significant (p = 0.008). CONCLUSION: High-sensitivity CRP was not correlated with CCS. The relationship between CRP and clinical events might not be related to atherosclerotic burden. Measures of inflammation, such as hs-CRP, and indices of atherosclerosis, such as CCS, are likely to provide distinct information regarding cardiovascular risk. |
format | Online Article Text |
id | pubmed-3721600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Clinics Cardive Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-37216002013-08-07 Association between C-reactive protein and coronary calcium score in coronary artery disease Hosseinsabet, Ali Mohebbi, Ahmad Almasi, Alireza Cardiovasc J Afr Cardiovascular Topics BACKGROUND: Both high-sensitivity C-reactive protein (hs-CRP) and spiral computed tomography coronary artery calcium score (CCS) are valid markers of cardiovascular risk. It is unknown whether hs-CRP is a marker of atherosclerotic burden or if it reflects a process leading to acute coronary events. METHODS AND RESULTS: We studied the association between hs-CRP and CCS in 143 patients who were candidates for coronary artery bypass grafting (CABG). In our cross-sectional study, we found no significant association between hs-CRP and the CCS in bivariant (p = 0.162) and multivariant (p = 0.062) analyses. However, in patients who did not use statins, this association was significant and positive in the bivariant analysis (p = 0.001), but in the multivariant analysis it was negative and significant (p = 0.008). CONCLUSION: High-sensitivity CRP was not correlated with CCS. The relationship between CRP and clinical events might not be related to atherosclerotic burden. Measures of inflammation, such as hs-CRP, and indices of atherosclerosis, such as CCS, are likely to provide distinct information regarding cardiovascular risk. Clinics Cardive Publishing 2009-04 /pmc/articles/PMC3721600/ /pubmed/19421644 Text en Copyright © 2010 Clinics Cardive Publishing http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cardiovascular Topics Hosseinsabet, Ali Mohebbi, Ahmad Almasi, Alireza Association between C-reactive protein and coronary calcium score in coronary artery disease |
title | Association between C-reactive protein and coronary calcium score in coronary artery disease |
title_full | Association between C-reactive protein and coronary calcium score in coronary artery disease |
title_fullStr | Association between C-reactive protein and coronary calcium score in coronary artery disease |
title_full_unstemmed | Association between C-reactive protein and coronary calcium score in coronary artery disease |
title_short | Association between C-reactive protein and coronary calcium score in coronary artery disease |
title_sort | association between c-reactive protein and coronary calcium score in coronary artery disease |
topic | Cardiovascular Topics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721600/ https://www.ncbi.nlm.nih.gov/pubmed/19421644 |
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