The Impact of Darwinian Evolution on Medicine: The Maternal Side of the Story

Complex disorders are common in the human population and are caused by interplay between genetic and environmental factors. Therefore the quest for the genetic basis of such disorders has much similarity to deciphering the genetic basis of macro-evolutionary processes, such as speciation. Here I dis...

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Detalles Bibliográficos
Autor principal: Mishmar, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rambam Health Care Campus 2010
Materias:
Rambam Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721657/
https://www.ncbi.nlm.nih.gov/pubmed/23908782
http://dx.doi.org/10.5041/RMMJ.10010
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author Mishmar, Dan
author_facet Mishmar, Dan
author_sort Mishmar, Dan
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description Complex disorders are common in the human population and are caused by interplay between genetic and environmental factors. Therefore the quest for the genetic basis of such disorders has much similarity to deciphering the genetic basis of macro-evolutionary processes, such as speciation. Here I discuss conceptual connections between the principles underlying and processes occurring in disease and evolution. Special focus is given to the tremendous mitochondrial genetic variability in the population and within individuals and the impact of both types of variability on evolutionary processes and diseases.
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spelling pubmed-37216572013-08-01 The Impact of Darwinian Evolution on Medicine: The Maternal Side of the Story Mishmar, Dan Rambam Maimonides Med J Rambam Forum Complex disorders are common in the human population and are caused by interplay between genetic and environmental factors. Therefore the quest for the genetic basis of such disorders has much similarity to deciphering the genetic basis of macro-evolutionary processes, such as speciation. Here I discuss conceptual connections between the principles underlying and processes occurring in disease and evolution. Special focus is given to the tremendous mitochondrial genetic variability in the population and within individuals and the impact of both types of variability on evolutionary processes and diseases. Rambam Health Care Campus 2010-07-02 /pmc/articles/PMC3721657/ /pubmed/23908782 http://dx.doi.org/10.5041/RMMJ.10010 Text en Copyright: © 2010 Dan Mishmar. This is an open-access article. All its content, except where otherwise noted, is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Rambam Forum
Mishmar, Dan
The Impact of Darwinian Evolution on Medicine: The Maternal Side of the Story
title The Impact of Darwinian Evolution on Medicine: The Maternal Side of the Story
title_full The Impact of Darwinian Evolution on Medicine: The Maternal Side of the Story
title_fullStr The Impact of Darwinian Evolution on Medicine: The Maternal Side of the Story
title_full_unstemmed The Impact of Darwinian Evolution on Medicine: The Maternal Side of the Story
title_short The Impact of Darwinian Evolution on Medicine: The Maternal Side of the Story
title_sort impact of darwinian evolution on medicine: the maternal side of the story
topic Rambam Forum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721657/
https://www.ncbi.nlm.nih.gov/pubmed/23908782
http://dx.doi.org/10.5041/RMMJ.10010
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