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Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa?

ABSTRACT: The chronic infection status suffered by HIV-infected individuals promotes chronic arterial inflammation and injury, which leads to dysfunction of the endothelium, atherosclerosis and thrombosis. Although HIV-1 subtype C is prevalent in South Africa and accounts for almost a third of the i...

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Autores principales: Fourie, C, Van Rooyen, J, Schutte, A, Pieters, M, Conradie, K, Hoekstra, T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Clinics Cardive Publishing 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721955/
https://www.ncbi.nlm.nih.gov/pubmed/21713302
http://dx.doi.org/10.5830/CVJA-2010-056
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author Fourie, C
Van Rooyen, J
Schutte, A
Pieters, M
Conradie, K
Hoekstra, T
author_facet Fourie, C
Van Rooyen, J
Schutte, A
Pieters, M
Conradie, K
Hoekstra, T
author_sort Fourie, C
collection PubMed
description ABSTRACT: The chronic infection status suffered by HIV-infected individuals promotes chronic arterial inflammation and injury, which leads to dysfunction of the endothelium, atherosclerosis and thrombosis. Although HIV-1 subtype C is prevalent in South Africa and accounts for almost a third of the infections worldwide, this subtype differs genetically from HIV-1 subtype B on which the majority of studies have been done. The objective of this study was to assess whether newly identified, never-treated, HIV-1-infected South African participants showed signs of endothelial dysfunction, accelerated atherosclerosis and increased blood coagulation. We compared 300 newly diagnosed (never antiretroviral-treated) HIV-infected participants to 300 age-, gender-, body mass index- and locality-matched uninfected controls. Levels of high-density lipoprotein cholesterol (HDL-C), triglycerides, interleukin-6 (IL-6), C-reactive protein (CRP), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), fibrinogen and plasminogen activator inhibitor-1 (PAI-1), and carotid radialis pulse wave velocity (cr-PWV) were determined. The HIV-infected participants showed lower HDL-C and higher IL-6, CRP, ICAM-1 and VCAM-1 levels compared to the uninfected controls. No differences in fibrinogen and PAI-1 levels were detected. A continuous positive trend of increasing age with cr-PWV was detected in the HIV-infected group. Our findings suggest inflammatory injury of the endothelium, pointing to endothelial dysfunction of never-treated HIV-1-infected South Africans of African ancestry. Although no indication of a prothrombotic state could be detected, there was an indication of accelerated vascular aging and probable early atherosclerosis in the older HIV-infected participants.
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spelling pubmed-37219552013-08-07 Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa? Fourie, C Van Rooyen, J Schutte, A Pieters, M Conradie, K Hoekstra, T Cardiovasc J Afr Cardiovascular Topics ABSTRACT: The chronic infection status suffered by HIV-infected individuals promotes chronic arterial inflammation and injury, which leads to dysfunction of the endothelium, atherosclerosis and thrombosis. Although HIV-1 subtype C is prevalent in South Africa and accounts for almost a third of the infections worldwide, this subtype differs genetically from HIV-1 subtype B on which the majority of studies have been done. The objective of this study was to assess whether newly identified, never-treated, HIV-1-infected South African participants showed signs of endothelial dysfunction, accelerated atherosclerosis and increased blood coagulation. We compared 300 newly diagnosed (never antiretroviral-treated) HIV-infected participants to 300 age-, gender-, body mass index- and locality-matched uninfected controls. Levels of high-density lipoprotein cholesterol (HDL-C), triglycerides, interleukin-6 (IL-6), C-reactive protein (CRP), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), fibrinogen and plasminogen activator inhibitor-1 (PAI-1), and carotid radialis pulse wave velocity (cr-PWV) were determined. The HIV-infected participants showed lower HDL-C and higher IL-6, CRP, ICAM-1 and VCAM-1 levels compared to the uninfected controls. No differences in fibrinogen and PAI-1 levels were detected. A continuous positive trend of increasing age with cr-PWV was detected in the HIV-infected group. Our findings suggest inflammatory injury of the endothelium, pointing to endothelial dysfunction of never-treated HIV-1-infected South Africans of African ancestry. Although no indication of a prothrombotic state could be detected, there was an indication of accelerated vascular aging and probable early atherosclerosis in the older HIV-infected participants. Clinics Cardive Publishing 2011-06 /pmc/articles/PMC3721955/ /pubmed/21713302 http://dx.doi.org/10.5830/CVJA-2010-056 Text en Copyright © 2010 Clinics Cardive Publishing http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cardiovascular Topics
Fourie, C
Van Rooyen, J
Schutte, A
Pieters, M
Conradie, K
Hoekstra, T
Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa?
title Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa?
title_full Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa?
title_fullStr Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa?
title_full_unstemmed Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa?
title_short Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa?
title_sort is hiv-1 infection associated with endothelial dysfunction in a population of african ancestry in south africa?
topic Cardiovascular Topics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721955/
https://www.ncbi.nlm.nih.gov/pubmed/21713302
http://dx.doi.org/10.5830/CVJA-2010-056
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