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Power spectral density analysis of physiological, rest and action tremor in Parkinson’s disease patients treated with deep brain stimulation

BACKGROUND: Observation of the signals recorded from the extremities of Parkinson’s disease patients showing rest and/or action tremor reveal a distinct high power resonance peak in the frequency band corresponding to tremor. The aim of the study was to investigate, using quantitative measures, how...

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Autores principales: Heida, Tjitske, Wentink, Eva Christine, Marani, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722015/
https://www.ncbi.nlm.nih.gov/pubmed/23834737
http://dx.doi.org/10.1186/1743-0003-10-70
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author Heida, Tjitske
Wentink, Eva Christine
Marani, Enrico
author_facet Heida, Tjitske
Wentink, Eva Christine
Marani, Enrico
author_sort Heida, Tjitske
collection PubMed
description BACKGROUND: Observation of the signals recorded from the extremities of Parkinson’s disease patients showing rest and/or action tremor reveal a distinct high power resonance peak in the frequency band corresponding to tremor. The aim of the study was to investigate, using quantitative measures, how clinically effective and less effective deep brain stimulation protocols redistribute movement power over the frequency bands associated with movement, pathological and physiological tremor, and whether normal physiological tremor may reappear during those periods that tremor is absent. METHODS: The power spectral density patterns of rest and action tremor were studied in 7 Parkinson’s disease patients treated with (bilateral) deep brain stimulation of the subthalamic nucleus. Two tests were carried out: 1) the patient was sitting at rest; 2) the patient performed a hand or foot tapping movement. Each test was repeated four times for each extremity with different stimulation settings applied during each repetition. Tremor intermittency was taken into account by classifying each 3-second window of the recorded angular velocity signals as a tremor or non-tremor window. RESULTS: The distribution of power over the low frequency band (<3.5 Hz – voluntary movement), tremor band (3.5-7.5 Hz) and high frequency band (>7.5 Hz – normal physiological tremor) revealed that rest and action tremor show a similar power-frequency shift related to tremor absence and presence: when tremor is present most power is contained in the tremor frequency band; when tremor is absent lower frequencies dominate. Even under resting conditions a relatively large low frequency component became prominent, which seemed to compensate for tremor. Tremor absence did not result in the reappearance of normal physiological tremor. CONCLUSION: Parkinson’s disease patients continuously balance between tremor and tremor suppression or compensation expressed by power shifts between the low frequency band and the tremor frequency band during rest and voluntary motor actions. This balance shows that the pathological tremor is either on or off, with the latter state not resembling that of a healthy subject. Deep brain stimulation can reverse the balance thereby either switching tremor on or off.
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spelling pubmed-37220152013-07-25 Power spectral density analysis of physiological, rest and action tremor in Parkinson’s disease patients treated with deep brain stimulation Heida, Tjitske Wentink, Eva Christine Marani, Enrico J Neuroeng Rehabil Research BACKGROUND: Observation of the signals recorded from the extremities of Parkinson’s disease patients showing rest and/or action tremor reveal a distinct high power resonance peak in the frequency band corresponding to tremor. The aim of the study was to investigate, using quantitative measures, how clinically effective and less effective deep brain stimulation protocols redistribute movement power over the frequency bands associated with movement, pathological and physiological tremor, and whether normal physiological tremor may reappear during those periods that tremor is absent. METHODS: The power spectral density patterns of rest and action tremor were studied in 7 Parkinson’s disease patients treated with (bilateral) deep brain stimulation of the subthalamic nucleus. Two tests were carried out: 1) the patient was sitting at rest; 2) the patient performed a hand or foot tapping movement. Each test was repeated four times for each extremity with different stimulation settings applied during each repetition. Tremor intermittency was taken into account by classifying each 3-second window of the recorded angular velocity signals as a tremor or non-tremor window. RESULTS: The distribution of power over the low frequency band (<3.5 Hz – voluntary movement), tremor band (3.5-7.5 Hz) and high frequency band (>7.5 Hz – normal physiological tremor) revealed that rest and action tremor show a similar power-frequency shift related to tremor absence and presence: when tremor is present most power is contained in the tremor frequency band; when tremor is absent lower frequencies dominate. Even under resting conditions a relatively large low frequency component became prominent, which seemed to compensate for tremor. Tremor absence did not result in the reappearance of normal physiological tremor. CONCLUSION: Parkinson’s disease patients continuously balance between tremor and tremor suppression or compensation expressed by power shifts between the low frequency band and the tremor frequency band during rest and voluntary motor actions. This balance shows that the pathological tremor is either on or off, with the latter state not resembling that of a healthy subject. Deep brain stimulation can reverse the balance thereby either switching tremor on or off. BioMed Central 2013-07-08 /pmc/articles/PMC3722015/ /pubmed/23834737 http://dx.doi.org/10.1186/1743-0003-10-70 Text en Copyright © 2013 Heida et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Heida, Tjitske
Wentink, Eva Christine
Marani, Enrico
Power spectral density analysis of physiological, rest and action tremor in Parkinson’s disease patients treated with deep brain stimulation
title Power spectral density analysis of physiological, rest and action tremor in Parkinson’s disease patients treated with deep brain stimulation
title_full Power spectral density analysis of physiological, rest and action tremor in Parkinson’s disease patients treated with deep brain stimulation
title_fullStr Power spectral density analysis of physiological, rest and action tremor in Parkinson’s disease patients treated with deep brain stimulation
title_full_unstemmed Power spectral density analysis of physiological, rest and action tremor in Parkinson’s disease patients treated with deep brain stimulation
title_short Power spectral density analysis of physiological, rest and action tremor in Parkinson’s disease patients treated with deep brain stimulation
title_sort power spectral density analysis of physiological, rest and action tremor in parkinson’s disease patients treated with deep brain stimulation
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722015/
https://www.ncbi.nlm.nih.gov/pubmed/23834737
http://dx.doi.org/10.1186/1743-0003-10-70
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