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Overcoming barriers and thresholds – signaling of oligomeric Aβ through the prion protein to Fyn
Evidence has been mounting for an involvement of the prion protein (PrP) in a molecular pathway assumed to play a critical role in the etiology of Alzheimer disease. A currently popular model sees oligomeric amyloid β (oAβ) peptides bind directly to PrP to emanate a signal that causes activation of...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722066/ https://www.ncbi.nlm.nih.gov/pubmed/23856335 http://dx.doi.org/10.1186/1750-1326-8-24 |