Characterization of Farmington virus, a novel virus from birds that is distantly related to members of the family Rhabdoviridae

BACKGROUND: Farmington virus (FARV) is a rhabdovirus that was isolated from a wild bird during an outbreak of epizootic eastern equine encephalitis on a pheasant farm in Connecticut, USA. FINDINGS: Analysis of the nearly complete genome sequence of the prototype CT AN 114 strain indicates that it en...

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Detalles Bibliográficos
Autores principales: Palacios, Gustavo, Forrester, Naomi L, Savji, Nazir, Travassos da Rosa, Amelia P A, Guzman, Hilda, DeToy, Kelly, Popov, Vsevolod L, Walker, Peter J, Lipkin, W Ian, Vasilakis, Nikos, Tesh, Robert B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722107/
https://www.ncbi.nlm.nih.gov/pubmed/23816310
http://dx.doi.org/10.1186/1743-422X-10-219
Descripción
Sumario:BACKGROUND: Farmington virus (FARV) is a rhabdovirus that was isolated from a wild bird during an outbreak of epizootic eastern equine encephalitis on a pheasant farm in Connecticut, USA. FINDINGS: Analysis of the nearly complete genome sequence of the prototype CT AN 114 strain indicates that it encodes the five canonical rhabdovirus structural proteins (N, P, M, G and L) with alternative ORFs (> 180 nt) in the N and G genes. Phenotypic and genetic characterization of FARV has confirmed that it is a novel rhabdovirus and probably represents a new species within the family Rhabdoviridae. CONCLUSIONS: In sum, our analysis indicates that FARV represents a new species within the family Rhabdoviridae.

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