A single mutation in the core domain of the lac repressor reduces leakiness

BACKGROUND: The lac operon provides cells with the ability to switch from glucose to lactose metabolism precisely when necessary. This metabolic switch is mediated by the lac repressor (LacI), which in the absence of lactose binds to the operator DNA sequence to inhibit transcription. Allosteric rea...

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Detalles Bibliográficos
Autores principales: Gatti-Lafranconi, Pietro, Dijkman, Willem P, Devenish, Sean RA, Hollfelder, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722110/
https://www.ncbi.nlm.nih.gov/pubmed/23834731
http://dx.doi.org/10.1186/1475-2859-12-67

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