Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na(+)/K(+)-ATPase

BACKGROUND: Surface-expressed Na(+)/K(+)-ATPase (NaK) has been suggested to function as a non-canonical cardiotonic steroid-binding receptor that activates multiple signaling cascades, especially in cancer cells. By contrast, the current study establishes a clear correlation between the IC(50)in vit...

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Detalles Bibliográficos
Autores principales: Moreno Y Banuls, Laetitia, Katz, Adriana, Miklos, Walter, Cimmino, Alessio, Tal, Daniel M, Ainbinder, Elena, Zehl, Martin, Urban, Ernst, Evidente, Antonio, Kopp, Brigitte, Berger, Walter, Feron, Olivier, Karlish, Steven, Kiss, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722118/
https://www.ncbi.nlm.nih.gov/pubmed/23621895
http://dx.doi.org/10.1186/1476-4598-12-33

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