Increased DNA Damage in Progression Of COPD: A Response By Poly(ADP-Ribose) Polymerase-1

Chronic oxidative stress (OS), a major mechanism of chronic obstructive pulmonary disease (COPD), may cause significant damage to DNA. Poly(ADP-ribose) polymerase (PARP)-1 is rapidly activated by OS-induced DNA lesions. However, the degree of DNA damage along with the evolution of COPD is unclear. I...

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Detalles Bibliográficos
Autores principales: Oit-Wiscombe, Ingrid, Virag, Laszlo, Soomets, Ursel, Altraja, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722143/
https://www.ncbi.nlm.nih.gov/pubmed/23894640
http://dx.doi.org/10.1371/journal.pone.0070333

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