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Is SOD1 loss of function involved in amyotrophic lateral sclerosis?
Mutations in the gene superoxide dismutase 1 (SOD1) are causative for familial forms of the neurodegenerative disease amyotrophic lateral sclerosis. When the first SOD1 mutations were identified they were postulated to give rise to amyotrophic lateral sclerosis through a loss of function mechanism,...
Autores principales: | Saccon, Rachele A., Bunton-Stasyshyn, Rosie K. A., Fisher, Elizabeth M.C., Fratta, Pietro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722346/ https://www.ncbi.nlm.nih.gov/pubmed/23687121 http://dx.doi.org/10.1093/brain/awt097 |
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