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Microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research

Plants produce a variety of secondary metabolites that possess strong physiological activities. Unfortunately, however, their production can suffer from a variety of serious problems, including low levels of productivity and heterogeneous quality, as well as difficulty in raw material supply. In con...

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Detalles Bibliográficos
Autores principales: SATO, Fumihiko, KUMAGAI, Hidehiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Academy 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722365/
https://www.ncbi.nlm.nih.gov/pubmed/23666088
http://dx.doi.org/10.2183/pjab.89.165
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author SATO, Fumihiko
KUMAGAI, Hidehiko
author_facet SATO, Fumihiko
KUMAGAI, Hidehiko
author_sort SATO, Fumihiko
collection PubMed
description Plants produce a variety of secondary metabolites that possess strong physiological activities. Unfortunately, however, their production can suffer from a variety of serious problems, including low levels of productivity and heterogeneous quality, as well as difficulty in raw material supply. In contrast, microorganisms can be used to produce their primary and some of their secondary metabolites in a controlled environment, thus assuring high levels of efficiency and uniform quality. In an attempt to overcome the problems associated with secondary metabolite production in plants, we developed a microbial platform for the production of plant isoquinoline alkaloids involving the unification of the microbial and plant metabolic pathways into a single system. The potential applications of this system have also been discussed.
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spelling pubmed-37223652013-08-09 Microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research SATO, Fumihiko KUMAGAI, Hidehiko Proc Jpn Acad Ser B Phys Biol Sci Review Plants produce a variety of secondary metabolites that possess strong physiological activities. Unfortunately, however, their production can suffer from a variety of serious problems, including low levels of productivity and heterogeneous quality, as well as difficulty in raw material supply. In contrast, microorganisms can be used to produce their primary and some of their secondary metabolites in a controlled environment, thus assuring high levels of efficiency and uniform quality. In an attempt to overcome the problems associated with secondary metabolite production in plants, we developed a microbial platform for the production of plant isoquinoline alkaloids involving the unification of the microbial and plant metabolic pathways into a single system. The potential applications of this system have also been discussed. The Japan Academy 2013-05-10 /pmc/articles/PMC3722365/ /pubmed/23666088 http://dx.doi.org/10.2183/pjab.89.165 Text en Copyright © 2013 The Japan Academy This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
SATO, Fumihiko
KUMAGAI, Hidehiko
Microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research
title Microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research
title_full Microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research
title_fullStr Microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research
title_full_unstemmed Microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research
title_short Microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research
title_sort microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722365/
https://www.ncbi.nlm.nih.gov/pubmed/23666088
http://dx.doi.org/10.2183/pjab.89.165
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