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Urine NGAL and KIM-1 in children and adolescents with hyperuricemia

BACKGROUND: The aim of this study was to test the hypothesis that urine levels of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) are enhanced in pediatric patients with hyperuricemia. METHODS: The study included 88 children and adolescents (60 males, 28 female...

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Autores principales: Tomczak, Justyna, Wasilewska, Anna, Milewski, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722436/
https://www.ncbi.nlm.nih.gov/pubmed/23673972
http://dx.doi.org/10.1007/s00467-013-2491-y
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author Tomczak, Justyna
Wasilewska, Anna
Milewski, Robert
author_facet Tomczak, Justyna
Wasilewska, Anna
Milewski, Robert
author_sort Tomczak, Justyna
collection PubMed
description BACKGROUND: The aim of this study was to test the hypothesis that urine levels of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) are enhanced in pediatric patients with hyperuricemia. METHODS: The study included 88 children and adolescents (60 males, 28 females) with a median age of 16 (range 11–18.5) years who had been referred to our department to rule out or confirm hypertension. The subjects were divided into two groups: the hyperuricemic (HU) group comprising 59 subjects with hyperuricemia (defined as serum uric acid >4.8 and >5.5 mg/dl in girls and boys, respectively) and the reference group comprising 29 patients with normouricemia. Urine NGAL and KIM-1 levels were evaluated using a commercially available kit. RESULTS: Concentrations of the examined biomarkers [urine NGAL, NGAL/creatinine (cr.) ratio, urine KIM-1, KIM-1/cr. ratio] were increased in the HU group compared with the reference group (p < 0.01). There were positive correlations between the serum uric acid and urine NGAL/cr. ratio (R = 0.67, p < 0.001) and the urine KIM-1/cr. ratio (R = 0.36, p < 0.001). In the multiple regression models, serum uric acid, systolic blood pressure and cholesterol accounted for more than 49 % of the variation in the NGAL/cr. ratio (R = 0.702, p < 0.001). In the second model, serum uric acid, gender, age and systolic blood pressure accounted for more than 36 % of the variation in the KIM-1/cr. ratio (R = 0.604, p < 0.001). CONCLUSION: We demonstrated that male, obese, hypertensive adolescents with hyperuricemia have higher urine NGAL and KIM-1 levels relative to a reference group with normouricemia.
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spelling pubmed-37224362013-07-31 Urine NGAL and KIM-1 in children and adolescents with hyperuricemia Tomczak, Justyna Wasilewska, Anna Milewski, Robert Pediatr Nephrol Original Article BACKGROUND: The aim of this study was to test the hypothesis that urine levels of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) are enhanced in pediatric patients with hyperuricemia. METHODS: The study included 88 children and adolescents (60 males, 28 females) with a median age of 16 (range 11–18.5) years who had been referred to our department to rule out or confirm hypertension. The subjects were divided into two groups: the hyperuricemic (HU) group comprising 59 subjects with hyperuricemia (defined as serum uric acid >4.8 and >5.5 mg/dl in girls and boys, respectively) and the reference group comprising 29 patients with normouricemia. Urine NGAL and KIM-1 levels were evaluated using a commercially available kit. RESULTS: Concentrations of the examined biomarkers [urine NGAL, NGAL/creatinine (cr.) ratio, urine KIM-1, KIM-1/cr. ratio] were increased in the HU group compared with the reference group (p < 0.01). There were positive correlations between the serum uric acid and urine NGAL/cr. ratio (R = 0.67, p < 0.001) and the urine KIM-1/cr. ratio (R = 0.36, p < 0.001). In the multiple regression models, serum uric acid, systolic blood pressure and cholesterol accounted for more than 49 % of the variation in the NGAL/cr. ratio (R = 0.702, p < 0.001). In the second model, serum uric acid, gender, age and systolic blood pressure accounted for more than 36 % of the variation in the KIM-1/cr. ratio (R = 0.604, p < 0.001). CONCLUSION: We demonstrated that male, obese, hypertensive adolescents with hyperuricemia have higher urine NGAL and KIM-1 levels relative to a reference group with normouricemia. Springer Berlin Heidelberg 2013-05-15 2013 /pmc/articles/PMC3722436/ /pubmed/23673972 http://dx.doi.org/10.1007/s00467-013-2491-y Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Tomczak, Justyna
Wasilewska, Anna
Milewski, Robert
Urine NGAL and KIM-1 in children and adolescents with hyperuricemia
title Urine NGAL and KIM-1 in children and adolescents with hyperuricemia
title_full Urine NGAL and KIM-1 in children and adolescents with hyperuricemia
title_fullStr Urine NGAL and KIM-1 in children and adolescents with hyperuricemia
title_full_unstemmed Urine NGAL and KIM-1 in children and adolescents with hyperuricemia
title_short Urine NGAL and KIM-1 in children and adolescents with hyperuricemia
title_sort urine ngal and kim-1 in children and adolescents with hyperuricemia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722436/
https://www.ncbi.nlm.nih.gov/pubmed/23673972
http://dx.doi.org/10.1007/s00467-013-2491-y
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