Identification of Substituted Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands

[Image: see text] A cell-based high-throughput screen to identify small molecular weight stimulators of the innate immune system revealed substituted pyrimido[5,4-b]indoles as potent NFκB activators. The most potent hit compound selectively stimulated Toll-like receptor 4 (TLR4) in human and mouse c...

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Detalles Bibliográficos
Autores principales: Chan, Michael, Hayashi, Tomoko, Mathewson, Richard D., Nour, Afshin, Hayashi, Yuki, Yao, Shiyin, Tawatao, Rommel I., Crain, Brian, Tsigelny, Igor F., Kouznetsova, Valentina L., Messer, Karen, Pu, Minya, Corr, Maripat, Carson, Dennis A., Cottam, Howard B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722616/
https://www.ncbi.nlm.nih.gov/pubmed/23656327
http://dx.doi.org/10.1021/jm301694x

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