Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes()

A local tissue-specific renin–angiotensin system (local RAS) has been identified in many organs. However, no report has described the role of a local RAS in the hypertrophic differentiation of chondrocytes. To examine the role of a local RAS in the hypertrophic differentiation, we activated angioten...

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Detalles Bibliográficos
Autores principales: Tsukamoto, Ichiro, Inoue, Shinji, Teramura, Takeshi, Takehara, Toshiyuki, Ohtani, Kazuhiro, Akagi, Masao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722649/
https://www.ncbi.nlm.nih.gov/pubmed/23905010
http://dx.doi.org/10.1016/j.fob.2013.07.001
Descripción
Sumario:A local tissue-specific renin–angiotensin system (local RAS) has been identified in many organs. However, no report has described the role of a local RAS in the hypertrophic differentiation of chondrocytes. To examine the role of a local RAS in the hypertrophic differentiation, we activated angiotensin II type 1 receptor (AT1R) and angiotensin II type 2 receptor (AT2R) separately in the cell line ATDC5, which involves differentiation from mesenchymal stem cells to hypertrophic chondrocytes. Activation of AT1R suppressed and activation of AT2R enhanced the expression of markers of hypertrophic differentiation, including type X collagen, matrix metalloproteinase 13 and runt-related transcription factor 2.

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