Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes()

A local tissue-specific renin–angiotensin system (local RAS) has been identified in many organs. However, no report has described the role of a local RAS in the hypertrophic differentiation of chondrocytes. To examine the role of a local RAS in the hypertrophic differentiation, we activated angioten...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsukamoto, Ichiro, Inoue, Shinji, Teramura, Takeshi, Takehara, Toshiyuki, Ohtani, Kazuhiro, Akagi, Masao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722649/
https://www.ncbi.nlm.nih.gov/pubmed/23905010
http://dx.doi.org/10.1016/j.fob.2013.07.001
_version_ 1782278220105646080
author Tsukamoto, Ichiro
Inoue, Shinji
Teramura, Takeshi
Takehara, Toshiyuki
Ohtani, Kazuhiro
Akagi, Masao
author_facet Tsukamoto, Ichiro
Inoue, Shinji
Teramura, Takeshi
Takehara, Toshiyuki
Ohtani, Kazuhiro
Akagi, Masao
author_sort Tsukamoto, Ichiro
collection PubMed
description A local tissue-specific renin–angiotensin system (local RAS) has been identified in many organs. However, no report has described the role of a local RAS in the hypertrophic differentiation of chondrocytes. To examine the role of a local RAS in the hypertrophic differentiation, we activated angiotensin II type 1 receptor (AT1R) and angiotensin II type 2 receptor (AT2R) separately in the cell line ATDC5, which involves differentiation from mesenchymal stem cells to hypertrophic chondrocytes. Activation of AT1R suppressed and activation of AT2R enhanced the expression of markers of hypertrophic differentiation, including type X collagen, matrix metalloproteinase 13 and runt-related transcription factor 2.
format Online
Article
Text
id pubmed-3722649
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-37226492013-07-31 Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes() Tsukamoto, Ichiro Inoue, Shinji Teramura, Takeshi Takehara, Toshiyuki Ohtani, Kazuhiro Akagi, Masao FEBS Open Bio Article A local tissue-specific renin–angiotensin system (local RAS) has been identified in many organs. However, no report has described the role of a local RAS in the hypertrophic differentiation of chondrocytes. To examine the role of a local RAS in the hypertrophic differentiation, we activated angiotensin II type 1 receptor (AT1R) and angiotensin II type 2 receptor (AT2R) separately in the cell line ATDC5, which involves differentiation from mesenchymal stem cells to hypertrophic chondrocytes. Activation of AT1R suppressed and activation of AT2R enhanced the expression of markers of hypertrophic differentiation, including type X collagen, matrix metalloproteinase 13 and runt-related transcription factor 2. Elsevier 2013-07-04 /pmc/articles/PMC3722649/ /pubmed/23905010 http://dx.doi.org/10.1016/j.fob.2013.07.001 Text en © 2013 The Authors http://creativecommons.org/licenses/BY-NC-ND/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Tsukamoto, Ichiro
Inoue, Shinji
Teramura, Takeshi
Takehara, Toshiyuki
Ohtani, Kazuhiro
Akagi, Masao
Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes()
title Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes()
title_full Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes()
title_fullStr Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes()
title_full_unstemmed Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes()
title_short Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes()
title_sort activating types 1 and 2 angiotensin ii receptors modulate the hypertrophic differentiation of chondrocytes()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722649/
https://www.ncbi.nlm.nih.gov/pubmed/23905010
http://dx.doi.org/10.1016/j.fob.2013.07.001
work_keys_str_mv AT tsukamotoichiro activatingtypes1and2angiotensiniireceptorsmodulatethehypertrophicdifferentiationofchondrocytes
AT inoueshinji activatingtypes1and2angiotensiniireceptorsmodulatethehypertrophicdifferentiationofchondrocytes
AT teramuratakeshi activatingtypes1and2angiotensiniireceptorsmodulatethehypertrophicdifferentiationofchondrocytes
AT takeharatoshiyuki activatingtypes1and2angiotensiniireceptorsmodulatethehypertrophicdifferentiationofchondrocytes
AT ohtanikazuhiro activatingtypes1and2angiotensiniireceptorsmodulatethehypertrophicdifferentiationofchondrocytes
AT akagimasao activatingtypes1and2angiotensiniireceptorsmodulatethehypertrophicdifferentiationofchondrocytes

Ejemplares similares