1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modelling Studies

The vascular endothelial growth factor receptor-2 (VEGFR-2) is a tyrosine kinase receptor involved in the growth and differentiation of endothelial cells that are implicated in tumor-associated angiogenesis. In this study, novel 1-aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas were synthesiz...

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Detalles Bibliográficos
Autores principales: Soares, Pedro, Costa, Raquel, Froufe, Hugo J. C., Calhelha, Ricardo C., Peixoto, Daniela, Ferreira, Isabel C. F. R., Abreu, Rui M. V., Soares, Raquel, Queiroz, Maria-João R. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722775/
https://www.ncbi.nlm.nih.gov/pubmed/23936775
http://dx.doi.org/10.1155/2013/154856

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