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Genome-wide association study identifies a novel variant in RAD51B associated with male breast cancer risk
We conducted a genome-wide association study of male breast cancer using 823 cases and 2,795 controls of European ancestry with validation in independent sample sets totalling 438 cases and 474 controls. A novel variant in RAD51B (14q24.1) was significantly associated with male breast cancer risk (P...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722904/ https://www.ncbi.nlm.nih.gov/pubmed/23001122 http://dx.doi.org/10.1038/ng.2417 |
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| author | Orr, Nick Lemnrau, Alina Cooke, Rosie Fletcher, Olivia Tomczyk, Katarzyna Jones, Michael Johnson, Nichola Lord, Christopher J Mitsopoulos, Costas Zvelebil, Marketa McDade, Simon S Buck, Gemma Blancher, Christine Consortium, KConFab Trainer, Alison H James, Paul A Bojesen, Stig E Bokmand, Susanne Nevanlinna, Heli Mattson, Johanna Friedman, Eitan Laitman, Yael Palli, Domenico Masala, Giovanna Zanna, Ines Ottini, Laura Giannini, Giuseppe Hollestelle, Antoinette van den Ouweland, Ans M.W. Novaković, Srdjan Krajc, Mateja Gago-Dominguez, Manuela Castelao, Jose Esteban Olsson, Håkan Hedenfalk, Ingrid Easton, Douglas F Pharoah, Paul DP Dunning, Alison M Bishop, D Timothy Neuhausen, Susan L Steele, Linda Houlston, Richard S Garcia-Closas, Montserrat Ashworth, Alan Swerdlow, Anthony J |
| author_facet | Orr, Nick Lemnrau, Alina Cooke, Rosie Fletcher, Olivia Tomczyk, Katarzyna Jones, Michael Johnson, Nichola Lord, Christopher J Mitsopoulos, Costas Zvelebil, Marketa McDade, Simon S Buck, Gemma Blancher, Christine Consortium, KConFab Trainer, Alison H James, Paul A Bojesen, Stig E Bokmand, Susanne Nevanlinna, Heli Mattson, Johanna Friedman, Eitan Laitman, Yael Palli, Domenico Masala, Giovanna Zanna, Ines Ottini, Laura Giannini, Giuseppe Hollestelle, Antoinette van den Ouweland, Ans M.W. Novaković, Srdjan Krajc, Mateja Gago-Dominguez, Manuela Castelao, Jose Esteban Olsson, Håkan Hedenfalk, Ingrid Easton, Douglas F Pharoah, Paul DP Dunning, Alison M Bishop, D Timothy Neuhausen, Susan L Steele, Linda Houlston, Richard S Garcia-Closas, Montserrat Ashworth, Alan Swerdlow, Anthony J |
| author_sort | Orr, Nick |
| collection | PubMed |
| description | We conducted a genome-wide association study of male breast cancer using 823 cases and 2,795 controls of European ancestry with validation in independent sample sets totalling 438 cases and 474 controls. A novel variant in RAD51B (14q24.1) was significantly associated with male breast cancer risk (P = 3.02 ×10(−13), odds ratio (OR) = 1.57). TOX3 (16q12.1) was also a susceptibility locus (P = 3.87 ×10(−15), OR = 1.50). |
| format | Online Article Text |
| id | pubmed-3722904 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-37229042013-07-25 Genome-wide association study identifies a novel variant in RAD51B associated with male breast cancer risk Orr, Nick Lemnrau, Alina Cooke, Rosie Fletcher, Olivia Tomczyk, Katarzyna Jones, Michael Johnson, Nichola Lord, Christopher J Mitsopoulos, Costas Zvelebil, Marketa McDade, Simon S Buck, Gemma Blancher, Christine Consortium, KConFab Trainer, Alison H James, Paul A Bojesen, Stig E Bokmand, Susanne Nevanlinna, Heli Mattson, Johanna Friedman, Eitan Laitman, Yael Palli, Domenico Masala, Giovanna Zanna, Ines Ottini, Laura Giannini, Giuseppe Hollestelle, Antoinette van den Ouweland, Ans M.W. Novaković, Srdjan Krajc, Mateja Gago-Dominguez, Manuela Castelao, Jose Esteban Olsson, Håkan Hedenfalk, Ingrid Easton, Douglas F Pharoah, Paul DP Dunning, Alison M Bishop, D Timothy Neuhausen, Susan L Steele, Linda Houlston, Richard S Garcia-Closas, Montserrat Ashworth, Alan Swerdlow, Anthony J Nat Genet Article We conducted a genome-wide association study of male breast cancer using 823 cases and 2,795 controls of European ancestry with validation in independent sample sets totalling 438 cases and 474 controls. A novel variant in RAD51B (14q24.1) was significantly associated with male breast cancer risk (P = 3.02 ×10(−13), odds ratio (OR) = 1.57). TOX3 (16q12.1) was also a susceptibility locus (P = 3.87 ×10(−15), OR = 1.50). 2012-09-23 2012-11 /pmc/articles/PMC3722904/ /pubmed/23001122 http://dx.doi.org/10.1038/ng.2417 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Orr, Nick Lemnrau, Alina Cooke, Rosie Fletcher, Olivia Tomczyk, Katarzyna Jones, Michael Johnson, Nichola Lord, Christopher J Mitsopoulos, Costas Zvelebil, Marketa McDade, Simon S Buck, Gemma Blancher, Christine Consortium, KConFab Trainer, Alison H James, Paul A Bojesen, Stig E Bokmand, Susanne Nevanlinna, Heli Mattson, Johanna Friedman, Eitan Laitman, Yael Palli, Domenico Masala, Giovanna Zanna, Ines Ottini, Laura Giannini, Giuseppe Hollestelle, Antoinette van den Ouweland, Ans M.W. Novaković, Srdjan Krajc, Mateja Gago-Dominguez, Manuela Castelao, Jose Esteban Olsson, Håkan Hedenfalk, Ingrid Easton, Douglas F Pharoah, Paul DP Dunning, Alison M Bishop, D Timothy Neuhausen, Susan L Steele, Linda Houlston, Richard S Garcia-Closas, Montserrat Ashworth, Alan Swerdlow, Anthony J Genome-wide association study identifies a novel variant in RAD51B associated with male breast cancer risk |
| title | Genome-wide association study identifies a novel variant in RAD51B associated with male breast cancer risk |
| title_full | Genome-wide association study identifies a novel variant in RAD51B associated with male breast cancer risk |
| title_fullStr | Genome-wide association study identifies a novel variant in RAD51B associated with male breast cancer risk |
| title_full_unstemmed | Genome-wide association study identifies a novel variant in RAD51B associated with male breast cancer risk |
| title_short | Genome-wide association study identifies a novel variant in RAD51B associated with male breast cancer risk |
| title_sort | genome-wide association study identifies a novel variant in rad51b associated with male breast cancer risk |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722904/ https://www.ncbi.nlm.nih.gov/pubmed/23001122 http://dx.doi.org/10.1038/ng.2417 |
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