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Epigenetics in Critical Illness: A New Frontier
Epigenetics is the study of alterations in the function of genes that do not involve changes in the DNA sequence. Within the critical care literature, it is a relatively new and exciting avenue of research in describing pathology, clinical course, and developing targeted therapies to improve outcome...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723097/ https://www.ncbi.nlm.nih.gov/pubmed/23936643 http://dx.doi.org/10.1155/2013/503686 |
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author | Graves, Brian T. Munro, Cindy L. |
author_facet | Graves, Brian T. Munro, Cindy L. |
author_sort | Graves, Brian T. |
collection | PubMed |
description | Epigenetics is the study of alterations in the function of genes that do not involve changes in the DNA sequence. Within the critical care literature, it is a relatively new and exciting avenue of research in describing pathology, clinical course, and developing targeted therapies to improve outcomes. In this paper, we highlight current research relative to critical care that is focused within the major epigenetic mechanisms of DNA methylation, histone modification, microRNA regulation, and composite epigenetic scoring. Within this emerging body of research it is quite clear that the novel therapies of the future will require clinicians to understand and navigate an even more complex and multivariate relationship between genetic, epigenetic, and biochemical mechanisms in conjunction with clinical presentation and course in order to significantly improve outcomes within the acute and critically ill population. |
format | Online Article Text |
id | pubmed-3723097 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37230972013-08-09 Epigenetics in Critical Illness: A New Frontier Graves, Brian T. Munro, Cindy L. Nurs Res Pract Review Article Epigenetics is the study of alterations in the function of genes that do not involve changes in the DNA sequence. Within the critical care literature, it is a relatively new and exciting avenue of research in describing pathology, clinical course, and developing targeted therapies to improve outcomes. In this paper, we highlight current research relative to critical care that is focused within the major epigenetic mechanisms of DNA methylation, histone modification, microRNA regulation, and composite epigenetic scoring. Within this emerging body of research it is quite clear that the novel therapies of the future will require clinicians to understand and navigate an even more complex and multivariate relationship between genetic, epigenetic, and biochemical mechanisms in conjunction with clinical presentation and course in order to significantly improve outcomes within the acute and critically ill population. Hindawi Publishing Corporation 2013 2013-07-09 /pmc/articles/PMC3723097/ /pubmed/23936643 http://dx.doi.org/10.1155/2013/503686 Text en Copyright © 2013 B. T. Graves and C. L. Munro. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Graves, Brian T. Munro, Cindy L. Epigenetics in Critical Illness: A New Frontier |
title | Epigenetics in Critical Illness: A New Frontier |
title_full | Epigenetics in Critical Illness: A New Frontier |
title_fullStr | Epigenetics in Critical Illness: A New Frontier |
title_full_unstemmed | Epigenetics in Critical Illness: A New Frontier |
title_short | Epigenetics in Critical Illness: A New Frontier |
title_sort | epigenetics in critical illness: a new frontier |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723097/ https://www.ncbi.nlm.nih.gov/pubmed/23936643 http://dx.doi.org/10.1155/2013/503686 |
work_keys_str_mv | AT gravesbriant epigeneticsincriticalillnessanewfrontier AT munrocindyl epigeneticsincriticalillnessanewfrontier |