Reassembly of Nucleosomes at the MLH1 Promoter Initiates Resilencing Following Decitabine Exposure

Hypomethylating agents reactivate tumor suppressor genes that are epigenetically silenced in cancer. Inevitably these genes are resilenced, leading to drug resistance. Using the MLH1 tumor suppressor gene as a model, we showed that decitabine-induced re-expression was dependent upon demethylation an...

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Detalles Bibliográficos
Autores principales: Hesson, Luke B., Patil, Vibha, Sloane, Mathew A., Nunez, Andrea C., Liu, Jia, Pimanda, John E., Ward, Robyn L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723495/
https://www.ncbi.nlm.nih.gov/pubmed/23935509
http://dx.doi.org/10.1371/journal.pgen.1003636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723495/
https://www.ncbi.nlm.nih.gov/pubmed/23935509
http://dx.doi.org/10.1371/journal.pgen.1003636

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