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Dengue and Other Common Causes of Acute Febrile Illness in Asia: An Active Surveillance Study in Children

BACKGROUND: Common causes of acute febrile illness in tropical countries have similar symptoms, which often mimic those of dengue. Accurate clinical diagnosis can be difficult without laboratory confirmation and disease burden is generally under-reported. Accurate, population-based, laboratory-confi...

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Autores principales: Capeding, Maria Rosario, Chua, Mary Noreen, Hadinegoro, Sri Rezeki, Hussain, Ismail I. H. M., Nallusamy, Revathy, Pitisuttithum, Punnee, Rusmil, Kusnandi, Thisyakorn, Usa, Thomas, Stephen J., Huu Tran, Ngoc, Wirawan, Dewa Nyoman, Yoon, In-Kyu, Bouckenooghe, Alain, Hutagalung, Yanee, Laot, Thelma, Wartel, Tram Anh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723539/
https://www.ncbi.nlm.nih.gov/pubmed/23936565
http://dx.doi.org/10.1371/journal.pntd.0002331
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author Capeding, Maria Rosario
Chua, Mary Noreen
Hadinegoro, Sri Rezeki
Hussain, Ismail I. H. M.
Nallusamy, Revathy
Pitisuttithum, Punnee
Rusmil, Kusnandi
Thisyakorn, Usa
Thomas, Stephen J.
Huu Tran, Ngoc
Wirawan, Dewa Nyoman
Yoon, In-Kyu
Bouckenooghe, Alain
Hutagalung, Yanee
Laot, Thelma
Wartel, Tram Anh
author_facet Capeding, Maria Rosario
Chua, Mary Noreen
Hadinegoro, Sri Rezeki
Hussain, Ismail I. H. M.
Nallusamy, Revathy
Pitisuttithum, Punnee
Rusmil, Kusnandi
Thisyakorn, Usa
Thomas, Stephen J.
Huu Tran, Ngoc
Wirawan, Dewa Nyoman
Yoon, In-Kyu
Bouckenooghe, Alain
Hutagalung, Yanee
Laot, Thelma
Wartel, Tram Anh
author_sort Capeding, Maria Rosario
collection PubMed
description BACKGROUND: Common causes of acute febrile illness in tropical countries have similar symptoms, which often mimic those of dengue. Accurate clinical diagnosis can be difficult without laboratory confirmation and disease burden is generally under-reported. Accurate, population-based, laboratory-confirmed incidence data on dengue and other causes of acute fever in dengue-endemic Asian countries are needed. METHODS AND PRINCIPAL FINDINGS: This prospective, multicenter, active fever surveillance, cohort study was conducted in selected centers in Indonesia, Malaysia, Philippines, Thailand and Vietnam to determine the incidence density of acute febrile episodes (≥38°C for ≥2 days) in 1,500 healthy children aged 2–14 years, followed for a mean 237 days. Causes of fever were assessed by testing acute and convalescent sera from febrile participants for dengue, chikungunya, hepatitis A, influenza A, leptospirosis, rickettsia, and Salmonella Typhi. Overall, 289 participants had acute fever, an incidence density of 33.6 per 100 person-years (95% CI: 30.0; 37.8); 57% were IgM-positive for at least one of these diseases. The most common causes of fever by IgM ELISA were chikungunya (in 35.0% of in febrile participants) and S. Typhi (in 29.4%). The overall incidence density of dengue per 100 person-years was 3.4 by nonstructural protein 1 (NS1) antigen positivity (95% CI: 2.4; 4.8) and 7.3 (95% CI: 5.7; 9.2) by serology. Dengue was diagnosed in 11.4% (95% CI: 8.0; 15.7) and 23.9% (95% CI: 19.1; 29.2) of febrile participants by NS1 positivity and serology, respectively. Of the febrile episodes not clinically diagnosed as dengue, 5.3% were dengue-positive by NS1 antigen testing and 16.0% were dengue-positive by serology. CONCLUSIONS: During the study period, the most common identified causes of pediatric acute febrile illness among the seven tested for were chikungunya, S. Typhi and dengue. Not all dengue cases were clinically diagnosed; laboratory confirmation is essential to refine disease burden estimates.
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spelling pubmed-37235392013-08-09 Dengue and Other Common Causes of Acute Febrile Illness in Asia: An Active Surveillance Study in Children Capeding, Maria Rosario Chua, Mary Noreen Hadinegoro, Sri Rezeki Hussain, Ismail I. H. M. Nallusamy, Revathy Pitisuttithum, Punnee Rusmil, Kusnandi Thisyakorn, Usa Thomas, Stephen J. Huu Tran, Ngoc Wirawan, Dewa Nyoman Yoon, In-Kyu Bouckenooghe, Alain Hutagalung, Yanee Laot, Thelma Wartel, Tram Anh PLoS Negl Trop Dis Research Article BACKGROUND: Common causes of acute febrile illness in tropical countries have similar symptoms, which often mimic those of dengue. Accurate clinical diagnosis can be difficult without laboratory confirmation and disease burden is generally under-reported. Accurate, population-based, laboratory-confirmed incidence data on dengue and other causes of acute fever in dengue-endemic Asian countries are needed. METHODS AND PRINCIPAL FINDINGS: This prospective, multicenter, active fever surveillance, cohort study was conducted in selected centers in Indonesia, Malaysia, Philippines, Thailand and Vietnam to determine the incidence density of acute febrile episodes (≥38°C for ≥2 days) in 1,500 healthy children aged 2–14 years, followed for a mean 237 days. Causes of fever were assessed by testing acute and convalescent sera from febrile participants for dengue, chikungunya, hepatitis A, influenza A, leptospirosis, rickettsia, and Salmonella Typhi. Overall, 289 participants had acute fever, an incidence density of 33.6 per 100 person-years (95% CI: 30.0; 37.8); 57% were IgM-positive for at least one of these diseases. The most common causes of fever by IgM ELISA were chikungunya (in 35.0% of in febrile participants) and S. Typhi (in 29.4%). The overall incidence density of dengue per 100 person-years was 3.4 by nonstructural protein 1 (NS1) antigen positivity (95% CI: 2.4; 4.8) and 7.3 (95% CI: 5.7; 9.2) by serology. Dengue was diagnosed in 11.4% (95% CI: 8.0; 15.7) and 23.9% (95% CI: 19.1; 29.2) of febrile participants by NS1 positivity and serology, respectively. Of the febrile episodes not clinically diagnosed as dengue, 5.3% were dengue-positive by NS1 antigen testing and 16.0% were dengue-positive by serology. CONCLUSIONS: During the study period, the most common identified causes of pediatric acute febrile illness among the seven tested for were chikungunya, S. Typhi and dengue. Not all dengue cases were clinically diagnosed; laboratory confirmation is essential to refine disease burden estimates. Public Library of Science 2013-07-25 /pmc/articles/PMC3723539/ /pubmed/23936565 http://dx.doi.org/10.1371/journal.pntd.0002331 Text en © 2013 Capeding et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Capeding, Maria Rosario
Chua, Mary Noreen
Hadinegoro, Sri Rezeki
Hussain, Ismail I. H. M.
Nallusamy, Revathy
Pitisuttithum, Punnee
Rusmil, Kusnandi
Thisyakorn, Usa
Thomas, Stephen J.
Huu Tran, Ngoc
Wirawan, Dewa Nyoman
Yoon, In-Kyu
Bouckenooghe, Alain
Hutagalung, Yanee
Laot, Thelma
Wartel, Tram Anh
Dengue and Other Common Causes of Acute Febrile Illness in Asia: An Active Surveillance Study in Children
title Dengue and Other Common Causes of Acute Febrile Illness in Asia: An Active Surveillance Study in Children
title_full Dengue and Other Common Causes of Acute Febrile Illness in Asia: An Active Surveillance Study in Children
title_fullStr Dengue and Other Common Causes of Acute Febrile Illness in Asia: An Active Surveillance Study in Children
title_full_unstemmed Dengue and Other Common Causes of Acute Febrile Illness in Asia: An Active Surveillance Study in Children
title_short Dengue and Other Common Causes of Acute Febrile Illness in Asia: An Active Surveillance Study in Children
title_sort dengue and other common causes of acute febrile illness in asia: an active surveillance study in children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723539/
https://www.ncbi.nlm.nih.gov/pubmed/23936565
http://dx.doi.org/10.1371/journal.pntd.0002331
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