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Decrease of miR-202-3p Expression, a Novel Tumor Suppressor, in Gastric Cancer

Emerging studies have indicated that microRNAs are involved in the development and progression of cancer. Here we found that miR-202-3p was frequently down-regulated in gastric cancer tissues. Overexpression of miR-202-3p in gastric cancer cells MKN-28 and BGC-823, markedly suppressed cell prolifera...

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Autores principales: Zhao, Yu, Li, Chenglong, Wang, Ming, Su, Liping, Qu, Ying, Li, Jianfang, Yu, Beiqin, Yan, Min, Yu, Yingyan, Liu, Bingya, Zhu, Zhenggang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723650/
https://www.ncbi.nlm.nih.gov/pubmed/23936094
http://dx.doi.org/10.1371/journal.pone.0069756
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author Zhao, Yu
Li, Chenglong
Wang, Ming
Su, Liping
Qu, Ying
Li, Jianfang
Yu, Beiqin
Yan, Min
Yu, Yingyan
Liu, Bingya
Zhu, Zhenggang
author_facet Zhao, Yu
Li, Chenglong
Wang, Ming
Su, Liping
Qu, Ying
Li, Jianfang
Yu, Beiqin
Yan, Min
Yu, Yingyan
Liu, Bingya
Zhu, Zhenggang
author_sort Zhao, Yu
collection PubMed
description Emerging studies have indicated that microRNAs are involved in the development and progression of cancer. Here we found that miR-202-3p was frequently down-regulated in gastric cancer tissues. Overexpression of miR-202-3p in gastric cancer cells MKN-28 and BGC-823, markedly suppressed cell proliferation and induced cell apoptosis both in vitro and in vivo. Furthermore, Gli1 expression was frequently positive in gastric cancer tissues and inversely correlated with miR-133b expression. We demonstrate that the transcriptional factor Gli1 was a target of miR-202-3p and plays an essential role as a mediator of the biological effects of miR-202-3p in gastric cancer. MiR-202-3p also inhibited the expression of γ-catenin and BCL-2. Taken together, these findings suggest that miR-202-3p may function as a novel tumor suppressor in gastric cancer and its anti-tumor activity may attribute the direct targeting and inhibition of Gli1.
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spelling pubmed-37236502013-08-09 Decrease of miR-202-3p Expression, a Novel Tumor Suppressor, in Gastric Cancer Zhao, Yu Li, Chenglong Wang, Ming Su, Liping Qu, Ying Li, Jianfang Yu, Beiqin Yan, Min Yu, Yingyan Liu, Bingya Zhu, Zhenggang PLoS One Research Article Emerging studies have indicated that microRNAs are involved in the development and progression of cancer. Here we found that miR-202-3p was frequently down-regulated in gastric cancer tissues. Overexpression of miR-202-3p in gastric cancer cells MKN-28 and BGC-823, markedly suppressed cell proliferation and induced cell apoptosis both in vitro and in vivo. Furthermore, Gli1 expression was frequently positive in gastric cancer tissues and inversely correlated with miR-133b expression. We demonstrate that the transcriptional factor Gli1 was a target of miR-202-3p and plays an essential role as a mediator of the biological effects of miR-202-3p in gastric cancer. MiR-202-3p also inhibited the expression of γ-catenin and BCL-2. Taken together, these findings suggest that miR-202-3p may function as a novel tumor suppressor in gastric cancer and its anti-tumor activity may attribute the direct targeting and inhibition of Gli1. Public Library of Science 2013-07-25 /pmc/articles/PMC3723650/ /pubmed/23936094 http://dx.doi.org/10.1371/journal.pone.0069756 Text en © 2013 Zhao et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zhao, Yu
Li, Chenglong
Wang, Ming
Su, Liping
Qu, Ying
Li, Jianfang
Yu, Beiqin
Yan, Min
Yu, Yingyan
Liu, Bingya
Zhu, Zhenggang
Decrease of miR-202-3p Expression, a Novel Tumor Suppressor, in Gastric Cancer
title Decrease of miR-202-3p Expression, a Novel Tumor Suppressor, in Gastric Cancer
title_full Decrease of miR-202-3p Expression, a Novel Tumor Suppressor, in Gastric Cancer
title_fullStr Decrease of miR-202-3p Expression, a Novel Tumor Suppressor, in Gastric Cancer
title_full_unstemmed Decrease of miR-202-3p Expression, a Novel Tumor Suppressor, in Gastric Cancer
title_short Decrease of miR-202-3p Expression, a Novel Tumor Suppressor, in Gastric Cancer
title_sort decrease of mir-202-3p expression, a novel tumor suppressor, in gastric cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723650/
https://www.ncbi.nlm.nih.gov/pubmed/23936094
http://dx.doi.org/10.1371/journal.pone.0069756
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