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Decrease of miR-202-3p Expression, a Novel Tumor Suppressor, in Gastric Cancer
Emerging studies have indicated that microRNAs are involved in the development and progression of cancer. Here we found that miR-202-3p was frequently down-regulated in gastric cancer tissues. Overexpression of miR-202-3p in gastric cancer cells MKN-28 and BGC-823, markedly suppressed cell prolifera...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723650/ https://www.ncbi.nlm.nih.gov/pubmed/23936094 http://dx.doi.org/10.1371/journal.pone.0069756 |
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author | Zhao, Yu Li, Chenglong Wang, Ming Su, Liping Qu, Ying Li, Jianfang Yu, Beiqin Yan, Min Yu, Yingyan Liu, Bingya Zhu, Zhenggang |
author_facet | Zhao, Yu Li, Chenglong Wang, Ming Su, Liping Qu, Ying Li, Jianfang Yu, Beiqin Yan, Min Yu, Yingyan Liu, Bingya Zhu, Zhenggang |
author_sort | Zhao, Yu |
collection | PubMed |
description | Emerging studies have indicated that microRNAs are involved in the development and progression of cancer. Here we found that miR-202-3p was frequently down-regulated in gastric cancer tissues. Overexpression of miR-202-3p in gastric cancer cells MKN-28 and BGC-823, markedly suppressed cell proliferation and induced cell apoptosis both in vitro and in vivo. Furthermore, Gli1 expression was frequently positive in gastric cancer tissues and inversely correlated with miR-133b expression. We demonstrate that the transcriptional factor Gli1 was a target of miR-202-3p and plays an essential role as a mediator of the biological effects of miR-202-3p in gastric cancer. MiR-202-3p also inhibited the expression of γ-catenin and BCL-2. Taken together, these findings suggest that miR-202-3p may function as a novel tumor suppressor in gastric cancer and its anti-tumor activity may attribute the direct targeting and inhibition of Gli1. |
format | Online Article Text |
id | pubmed-3723650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37236502013-08-09 Decrease of miR-202-3p Expression, a Novel Tumor Suppressor, in Gastric Cancer Zhao, Yu Li, Chenglong Wang, Ming Su, Liping Qu, Ying Li, Jianfang Yu, Beiqin Yan, Min Yu, Yingyan Liu, Bingya Zhu, Zhenggang PLoS One Research Article Emerging studies have indicated that microRNAs are involved in the development and progression of cancer. Here we found that miR-202-3p was frequently down-regulated in gastric cancer tissues. Overexpression of miR-202-3p in gastric cancer cells MKN-28 and BGC-823, markedly suppressed cell proliferation and induced cell apoptosis both in vitro and in vivo. Furthermore, Gli1 expression was frequently positive in gastric cancer tissues and inversely correlated with miR-133b expression. We demonstrate that the transcriptional factor Gli1 was a target of miR-202-3p and plays an essential role as a mediator of the biological effects of miR-202-3p in gastric cancer. MiR-202-3p also inhibited the expression of γ-catenin and BCL-2. Taken together, these findings suggest that miR-202-3p may function as a novel tumor suppressor in gastric cancer and its anti-tumor activity may attribute the direct targeting and inhibition of Gli1. Public Library of Science 2013-07-25 /pmc/articles/PMC3723650/ /pubmed/23936094 http://dx.doi.org/10.1371/journal.pone.0069756 Text en © 2013 Zhao et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Zhao, Yu Li, Chenglong Wang, Ming Su, Liping Qu, Ying Li, Jianfang Yu, Beiqin Yan, Min Yu, Yingyan Liu, Bingya Zhu, Zhenggang Decrease of miR-202-3p Expression, a Novel Tumor Suppressor, in Gastric Cancer |
title | Decrease of miR-202-3p Expression, a Novel Tumor Suppressor, in Gastric Cancer |
title_full | Decrease of miR-202-3p Expression, a Novel Tumor Suppressor, in Gastric Cancer |
title_fullStr | Decrease of miR-202-3p Expression, a Novel Tumor Suppressor, in Gastric Cancer |
title_full_unstemmed | Decrease of miR-202-3p Expression, a Novel Tumor Suppressor, in Gastric Cancer |
title_short | Decrease of miR-202-3p Expression, a Novel Tumor Suppressor, in Gastric Cancer |
title_sort | decrease of mir-202-3p expression, a novel tumor suppressor, in gastric cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723650/ https://www.ncbi.nlm.nih.gov/pubmed/23936094 http://dx.doi.org/10.1371/journal.pone.0069756 |
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