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Meta-analysis identifies four new loci associated with testicular germ cell tumor
We conducted a meta-analysis to identify new loci for testicular germ cell tumor (TGCT) susceptibility. In the discovery phase, 931 affected individuals and 1,975 controls from three genome wide association studies (GWAS) were analyzed. Replication was conducted in six independent sample sets totali...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723930/ https://www.ncbi.nlm.nih.gov/pubmed/23666239 http://dx.doi.org/10.1038/ng.2634 |
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| author | Chung, Charles C. Kanetsky, Peter A. Wang, Zhaoming Hildebrandt, Michelle A. T. Koster, Roelof Skotheim, Rolf I. Kratz, Christian P. Turnbull, Clare Cortessis, Victoria K. Bakken, Anne C. Bishop, D. Timothy Cook, Michael B. Erickson, R. Loren Fosså, Sophie D. Jacobs, Kevin B. Korde, Larissa A. Kraggerud, Sigrid M. Lothe, Ragnhild A. Loud, Jennifer T. Rahman, Nazneen Skinner, Eila C. Thomas, Duncan C. Wu, Xifeng Yeager, Meredith Schumacher, Fredrick R. Greene, Mark H. Schwartz, Stephen M. McGlynn, Katherine A. Chanock, Stephen J. Nathanson, Katherine L. |
| author_facet | Chung, Charles C. Kanetsky, Peter A. Wang, Zhaoming Hildebrandt, Michelle A. T. Koster, Roelof Skotheim, Rolf I. Kratz, Christian P. Turnbull, Clare Cortessis, Victoria K. Bakken, Anne C. Bishop, D. Timothy Cook, Michael B. Erickson, R. Loren Fosså, Sophie D. Jacobs, Kevin B. Korde, Larissa A. Kraggerud, Sigrid M. Lothe, Ragnhild A. Loud, Jennifer T. Rahman, Nazneen Skinner, Eila C. Thomas, Duncan C. Wu, Xifeng Yeager, Meredith Schumacher, Fredrick R. Greene, Mark H. Schwartz, Stephen M. McGlynn, Katherine A. Chanock, Stephen J. Nathanson, Katherine L. |
| author_sort | Chung, Charles C. |
| collection | PubMed |
| description | We conducted a meta-analysis to identify new loci for testicular germ cell tumor (TGCT) susceptibility. In the discovery phase, 931 affected individuals and 1,975 controls from three genome wide association studies (GWAS) were analyzed. Replication was conducted in six independent sample sets totaling 3,211 affected individuals and 7,591 controls. In the combined analysis, TGCT risk was significantly associated with markers at four novel loci: 4q22.2 in HPGDS (per allele odds ratio (OR) 1.19, 95%CI 1.12–1.26, P = 1.11×10(−8)); 7p22.3 in MAD1L1 (OR 1.21, 95%CI 1.14–1.29, P = 5.59×10(−9)); 16q22.3 in RFWD3 (OR 1.26, 95%CI 1.18–1.34, P = 5.15×10(−12)); and 17q22 (rs9905704; OR 1.27, 95%CI 1.18–1.33; P = 4.32×10(−13), and rs7221274; OR 1.20, 95%CI 1.12–1.28 P = 4.04×10(−9)), a locus which includes TEX14, RAD51C and PPM1E. The new TGCT susceptibility loci contain biologically plausible genes encoding proteins important for male germ cell development, chromosomal segregation and DNA damage response. |
| format | Online Article Text |
| id | pubmed-3723930 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-37239302013-12-01 Meta-analysis identifies four new loci associated with testicular germ cell tumor Chung, Charles C. Kanetsky, Peter A. Wang, Zhaoming Hildebrandt, Michelle A. T. Koster, Roelof Skotheim, Rolf I. Kratz, Christian P. Turnbull, Clare Cortessis, Victoria K. Bakken, Anne C. Bishop, D. Timothy Cook, Michael B. Erickson, R. Loren Fosså, Sophie D. Jacobs, Kevin B. Korde, Larissa A. Kraggerud, Sigrid M. Lothe, Ragnhild A. Loud, Jennifer T. Rahman, Nazneen Skinner, Eila C. Thomas, Duncan C. Wu, Xifeng Yeager, Meredith Schumacher, Fredrick R. Greene, Mark H. Schwartz, Stephen M. McGlynn, Katherine A. Chanock, Stephen J. Nathanson, Katherine L. Nat Genet Article We conducted a meta-analysis to identify new loci for testicular germ cell tumor (TGCT) susceptibility. In the discovery phase, 931 affected individuals and 1,975 controls from three genome wide association studies (GWAS) were analyzed. Replication was conducted in six independent sample sets totaling 3,211 affected individuals and 7,591 controls. In the combined analysis, TGCT risk was significantly associated with markers at four novel loci: 4q22.2 in HPGDS (per allele odds ratio (OR) 1.19, 95%CI 1.12–1.26, P = 1.11×10(−8)); 7p22.3 in MAD1L1 (OR 1.21, 95%CI 1.14–1.29, P = 5.59×10(−9)); 16q22.3 in RFWD3 (OR 1.26, 95%CI 1.18–1.34, P = 5.15×10(−12)); and 17q22 (rs9905704; OR 1.27, 95%CI 1.18–1.33; P = 4.32×10(−13), and rs7221274; OR 1.20, 95%CI 1.12–1.28 P = 4.04×10(−9)), a locus which includes TEX14, RAD51C and PPM1E. The new TGCT susceptibility loci contain biologically plausible genes encoding proteins important for male germ cell development, chromosomal segregation and DNA damage response. 2013-05-12 2013-06 /pmc/articles/PMC3723930/ /pubmed/23666239 http://dx.doi.org/10.1038/ng.2634 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Chung, Charles C. Kanetsky, Peter A. Wang, Zhaoming Hildebrandt, Michelle A. T. Koster, Roelof Skotheim, Rolf I. Kratz, Christian P. Turnbull, Clare Cortessis, Victoria K. Bakken, Anne C. Bishop, D. Timothy Cook, Michael B. Erickson, R. Loren Fosså, Sophie D. Jacobs, Kevin B. Korde, Larissa A. Kraggerud, Sigrid M. Lothe, Ragnhild A. Loud, Jennifer T. Rahman, Nazneen Skinner, Eila C. Thomas, Duncan C. Wu, Xifeng Yeager, Meredith Schumacher, Fredrick R. Greene, Mark H. Schwartz, Stephen M. McGlynn, Katherine A. Chanock, Stephen J. Nathanson, Katherine L. Meta-analysis identifies four new loci associated with testicular germ cell tumor |
| title | Meta-analysis identifies four new loci associated with testicular germ cell tumor |
| title_full | Meta-analysis identifies four new loci associated with testicular germ cell tumor |
| title_fullStr | Meta-analysis identifies four new loci associated with testicular germ cell tumor |
| title_full_unstemmed | Meta-analysis identifies four new loci associated with testicular germ cell tumor |
| title_short | Meta-analysis identifies four new loci associated with testicular germ cell tumor |
| title_sort | meta-analysis identifies four new loci associated with testicular germ cell tumor |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723930/ https://www.ncbi.nlm.nih.gov/pubmed/23666239 http://dx.doi.org/10.1038/ng.2634 |
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