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Telomerase downregulation induces proapoptotic genes expression and initializes breast cancer cells apoptosis followed by DNA fragmentation in a cell type dependent manner

The aim of the study was to analyze the consequence of silencing genes coding for the key subunits of the telomerase complex, i.e. TERT, TERC and TP1 in human breast cancer MCF7 and MDA-MB-231cells. The transfection was performed using Lipofectamine2000 and pooled siRNAs. The cytotoxic and/or antipr...

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Detalles Bibliográficos
Autores principales:	Rubis, Blazej, Holysz, Hanna, Gladych, Marta, Toton, Ewa, Paszel, Anna, Lisiak, Natalia, Kaczmarek, Mariusz, Hofmann, Johann, Rybczynska, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723976/ https://www.ncbi.nlm.nih.gov/pubmed/23677713 http://dx.doi.org/10.1007/s11033-013-2600-9

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