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Idiopathic generalized epilepsy: Phenotypic and electroencephalographic observations in a large cohort from South India

PURPOSE: We studied the phenotype and electroencephalographic (EEG) features, and therapeutic aspects of idiopathic generalized epilepsies (IGEs) in South Indian population. PATIENTS AND METHODS: This prospective cross-sectional hospital-based study was carried out on non-consecutive 287 patients (a...

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Autores principales: Sinha, Sanjib, Pramod, M. N., Dilipkumar, S., Satishchandra, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724066/
https://www.ncbi.nlm.nih.gov/pubmed/23956556
http://dx.doi.org/10.4103/0972-2327.112455
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author Sinha, Sanjib
Pramod, M. N.
Dilipkumar, S.
Satishchandra, P.
author_facet Sinha, Sanjib
Pramod, M. N.
Dilipkumar, S.
Satishchandra, P.
author_sort Sinha, Sanjib
collection PubMed
description PURPOSE: We studied the phenotype and electroencephalographic (EEG) features, and therapeutic aspects of idiopathic generalized epilepsies (IGEs) in South Indian population. PATIENTS AND METHODS: This prospective cross-sectional hospital-based study was carried out on non-consecutive 287 patients (age 22.2 ± 7.7 years; M:F = 139:148) with IGE syndrome. Their clinical and EEG observations were analyzed. RESULTS: Majority of the patients had onset of seizures <20 years of age (n = 178; 62%). Thirty one patients (10.8%) had family history of epilepsy. Nearly half of them (49.9%) had <5 years of duration of seizures. The type of IGEs included Juvenile myoclonic epilepsy (JME): 115 (40.1%); IGE with generalized tonic-clonic seizures (GTCS) only: 102 (39.02%); childhood absence epilepsy (CAE): 35 (12.2%); GTCS on awakening: 15 (5.2%); Juvenile absence epilepsy (JAE): 11 (3.8%); and unclassified seizures: 9 (3.1%). The triggering factors noted in 45% were sleep deprivation (20%), non-compliance and stress in 5% each. The EEG (n = 280) showed epileptiform discharges in about 50% of patients. Epileptiform discharges during activation was observed in 40/249 patients (16.1%): Hyperventilation in 32 (12.8%) and photic stimulation in 19 (7.6%). The seizures were well controlled with anti-epileptic drugs (AEDs) in 232 (80.8%) patients and among them, 225 (78.4%) patients were on monotherapy. Valproate (n = 131) was the most frequently prescribed as monotherapy. CONCLUSIONS: This is one of the largest cohort of patients with IGE. This study reiterates the importance of segregating IGE syndrome and such analysis will aid to the current understanding and management.
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spelling pubmed-37240662013-08-16 Idiopathic generalized epilepsy: Phenotypic and electroencephalographic observations in a large cohort from South India Sinha, Sanjib Pramod, M. N. Dilipkumar, S. Satishchandra, P. Ann Indian Acad Neurol Original Article PURPOSE: We studied the phenotype and electroencephalographic (EEG) features, and therapeutic aspects of idiopathic generalized epilepsies (IGEs) in South Indian population. PATIENTS AND METHODS: This prospective cross-sectional hospital-based study was carried out on non-consecutive 287 patients (age 22.2 ± 7.7 years; M:F = 139:148) with IGE syndrome. Their clinical and EEG observations were analyzed. RESULTS: Majority of the patients had onset of seizures <20 years of age (n = 178; 62%). Thirty one patients (10.8%) had family history of epilepsy. Nearly half of them (49.9%) had <5 years of duration of seizures. The type of IGEs included Juvenile myoclonic epilepsy (JME): 115 (40.1%); IGE with generalized tonic-clonic seizures (GTCS) only: 102 (39.02%); childhood absence epilepsy (CAE): 35 (12.2%); GTCS on awakening: 15 (5.2%); Juvenile absence epilepsy (JAE): 11 (3.8%); and unclassified seizures: 9 (3.1%). The triggering factors noted in 45% were sleep deprivation (20%), non-compliance and stress in 5% each. The EEG (n = 280) showed epileptiform discharges in about 50% of patients. Epileptiform discharges during activation was observed in 40/249 patients (16.1%): Hyperventilation in 32 (12.8%) and photic stimulation in 19 (7.6%). The seizures were well controlled with anti-epileptic drugs (AEDs) in 232 (80.8%) patients and among them, 225 (78.4%) patients were on monotherapy. Valproate (n = 131) was the most frequently prescribed as monotherapy. CONCLUSIONS: This is one of the largest cohort of patients with IGE. This study reiterates the importance of segregating IGE syndrome and such analysis will aid to the current understanding and management. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3724066/ /pubmed/23956556 http://dx.doi.org/10.4103/0972-2327.112455 Text en Copyright: © Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sinha, Sanjib
Pramod, M. N.
Dilipkumar, S.
Satishchandra, P.
Idiopathic generalized epilepsy: Phenotypic and electroencephalographic observations in a large cohort from South India
title Idiopathic generalized epilepsy: Phenotypic and electroencephalographic observations in a large cohort from South India
title_full Idiopathic generalized epilepsy: Phenotypic and electroencephalographic observations in a large cohort from South India
title_fullStr Idiopathic generalized epilepsy: Phenotypic and electroencephalographic observations in a large cohort from South India
title_full_unstemmed Idiopathic generalized epilepsy: Phenotypic and electroencephalographic observations in a large cohort from South India
title_short Idiopathic generalized epilepsy: Phenotypic and electroencephalographic observations in a large cohort from South India
title_sort idiopathic generalized epilepsy: phenotypic and electroencephalographic observations in a large cohort from south india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724066/
https://www.ncbi.nlm.nih.gov/pubmed/23956556
http://dx.doi.org/10.4103/0972-2327.112455
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