Insulin and insulin-like growth factor signaling increases proliferation and hyperplasia of the ovarian surface epithelium and decreases follicular integrity through upregulation of the PI3-kinase pathway

BACKGROUND: The ovarian surface epithelium responds to cytokines and hormonal cues to initiate proliferation and migration following ovulation. Although insulin and IGF are potent proliferative factors for the ovarian surface epithelium and IGF is required for follicle development, increased insulin...

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Detalles Bibliográficos
Autores principales: King, Shelby M, Modi, Dimple A, Eddie, Sharon L, Burdette, Joanna E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724505/
https://www.ncbi.nlm.nih.gov/pubmed/23388061
http://dx.doi.org/10.1186/1757-2215-6-12

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