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The clinical significance of lymphangiogenesis in renal cell carcinoma
BACKGROUND: The formation of lymphatic vessels (lymphangiogenesis) occurs in tumor tissues and is crucial for tumor development and progression in some cancers. Lymphangiogenesis and its clinical effect on renal cell carcinoma have been less thoroughly investigated in comparison with angiogenesis. T...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724570/ https://www.ncbi.nlm.nih.gov/pubmed/23881345 http://dx.doi.org/10.12659/MSM.883981 |
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author | Dębiński, Paweł Dembowski, Janusz Kowal, Paweł Szydełko, Tomasz Kołodziej, Anna Małkiewicz, Bartosz Tupikowski, Krzysztof Zdrojowy, Romuald |
author_facet | Dębiński, Paweł Dembowski, Janusz Kowal, Paweł Szydełko, Tomasz Kołodziej, Anna Małkiewicz, Bartosz Tupikowski, Krzysztof Zdrojowy, Romuald |
author_sort | Dębiński, Paweł |
collection | PubMed |
description | BACKGROUND: The formation of lymphatic vessels (lymphangiogenesis) occurs in tumor tissues and is crucial for tumor development and progression in some cancers. Lymphangiogenesis and its clinical effect on renal cell carcinoma have been less thoroughly investigated in comparison with angiogenesis. The aim of this study was to evaluate the role of lymphangiogenesis as a prognostic factor in renal cell carcinoma (RCC). MATERIAL/METHODS: The expression of peritumoral/intratumoral lymphatics was studied by immunohistochemical methods in paraffin-embedded nephrectomy specimens from 133 patients with clear cell carcinoma. Patients were divided into 3 groups depending on postoperative follow-up: I) patients without metastases, II) patients with metastases during follow-up, and III) patients with metastases during the operation. Peritumoral lymphatics (PTL) and intratumoral lymphatics (ITL) were immunostained with a D2-40 antibody. RESULTS: The mean number of PTL present in each group was I=14.1, II=10.6, III=12.1. The mean number of ITL present in each group was I=0.7, II=2.3, III=2.3. The 3 groups showed statistically significant differences only in the case of ITL. A mean count of ITL ≥1 is significantly associated with an increased risk of regional lymph node involvement and distant metastasis. Patients with expression ITL >0.2 and PTL ≤15.2 had a significantly shorter cancer-specific survival. CONCLUSIONS: The number of ITL showed an association with more aggressive cases of RCC and progression of disease. Therefore, the level of expression ITL, together with stage and histological grading, may provide valuable predictive information about the outcome of treatment. |
format | Online Article Text |
id | pubmed-3724570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-37245702013-07-30 The clinical significance of lymphangiogenesis in renal cell carcinoma Dębiński, Paweł Dembowski, Janusz Kowal, Paweł Szydełko, Tomasz Kołodziej, Anna Małkiewicz, Bartosz Tupikowski, Krzysztof Zdrojowy, Romuald Med Sci Monit Clinical Research BACKGROUND: The formation of lymphatic vessels (lymphangiogenesis) occurs in tumor tissues and is crucial for tumor development and progression in some cancers. Lymphangiogenesis and its clinical effect on renal cell carcinoma have been less thoroughly investigated in comparison with angiogenesis. The aim of this study was to evaluate the role of lymphangiogenesis as a prognostic factor in renal cell carcinoma (RCC). MATERIAL/METHODS: The expression of peritumoral/intratumoral lymphatics was studied by immunohistochemical methods in paraffin-embedded nephrectomy specimens from 133 patients with clear cell carcinoma. Patients were divided into 3 groups depending on postoperative follow-up: I) patients without metastases, II) patients with metastases during follow-up, and III) patients with metastases during the operation. Peritumoral lymphatics (PTL) and intratumoral lymphatics (ITL) were immunostained with a D2-40 antibody. RESULTS: The mean number of PTL present in each group was I=14.1, II=10.6, III=12.1. The mean number of ITL present in each group was I=0.7, II=2.3, III=2.3. The 3 groups showed statistically significant differences only in the case of ITL. A mean count of ITL ≥1 is significantly associated with an increased risk of regional lymph node involvement and distant metastasis. Patients with expression ITL >0.2 and PTL ≤15.2 had a significantly shorter cancer-specific survival. CONCLUSIONS: The number of ITL showed an association with more aggressive cases of RCC and progression of disease. Therefore, the level of expression ITL, together with stage and histological grading, may provide valuable predictive information about the outcome of treatment. International Scientific Literature, Inc. 2013-07-24 /pmc/articles/PMC3724570/ /pubmed/23881345 http://dx.doi.org/10.12659/MSM.883981 Text en © Med Sci Monit, 2013 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License |
spellingShingle | Clinical Research Dębiński, Paweł Dembowski, Janusz Kowal, Paweł Szydełko, Tomasz Kołodziej, Anna Małkiewicz, Bartosz Tupikowski, Krzysztof Zdrojowy, Romuald The clinical significance of lymphangiogenesis in renal cell carcinoma |
title | The clinical significance of lymphangiogenesis in renal cell carcinoma |
title_full | The clinical significance of lymphangiogenesis in renal cell carcinoma |
title_fullStr | The clinical significance of lymphangiogenesis in renal cell carcinoma |
title_full_unstemmed | The clinical significance of lymphangiogenesis in renal cell carcinoma |
title_short | The clinical significance of lymphangiogenesis in renal cell carcinoma |
title_sort | clinical significance of lymphangiogenesis in renal cell carcinoma |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724570/ https://www.ncbi.nlm.nih.gov/pubmed/23881345 http://dx.doi.org/10.12659/MSM.883981 |
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