Cargando…

A Cross-sectional Study of the Impact of Blood Selenium on Blood and Urinary Arsenic Concentrations in Bangladesh

BACKGROUND: Arsenic can naturally occur in the groundwater without an anthropogenic source of contamination. In Bangladesh over 50 million people are exposed to naturally occurring arsenic concentrations exceeding the World Health Organization’s guideline of 10 μg/L. Selenium and arsenic have been s...

Descripción completa

Detalles Bibliográficos
Autores principales: George, Christine Marie, Gamble, Mary, Slavkovich, Vesna, Levy, Diane, Ahmed, Alauddin, Ahsan, Habibul, Graziano, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724573/
https://www.ncbi.nlm.nih.gov/pubmed/23816141
http://dx.doi.org/10.1186/1476-069X-12-52
_version_ 1782476696712118272
author George, Christine Marie
Gamble, Mary
Slavkovich, Vesna
Levy, Diane
Ahmed, Alauddin
Ahsan, Habibul
Graziano, Joseph
author_facet George, Christine Marie
Gamble, Mary
Slavkovich, Vesna
Levy, Diane
Ahmed, Alauddin
Ahsan, Habibul
Graziano, Joseph
author_sort George, Christine Marie
collection PubMed
description BACKGROUND: Arsenic can naturally occur in the groundwater without an anthropogenic source of contamination. In Bangladesh over 50 million people are exposed to naturally occurring arsenic concentrations exceeding the World Health Organization’s guideline of 10 μg/L. Selenium and arsenic have been shown to facilitate the excretion of each other in bile. Recent evidence suggests that selenium may play a role in arsenic elimination by forming a selenium-arsenic conjugate in the liver before excretion into the bile. METHODS: A cross-sectional study of 1601 adults and 287 children was conducted to assess the relationship between blood selenium and urinary and blood arsenic in a study population residing in a moderately arsenic-contaminated rural area in Bangladesh. RESULTS: The results of this study indicate a statistically significant inverse relationship between blood selenium and urinary arsenic concentrations in both adult and pediatric populations in rural Bangladesh after adjustment for age, sex, Body Mass Index, plasma folate and B12 (in children), and ever smoking and current betel nut use (in adults). In addition, there appears to be a statistically significant inverse relationship between blood selenium and blood arsenic in children. CONCLUSIONS: Our results suggest that selenium is inversely associated with biomarkers of arsenic burden in both adults and children. These findings support the hypothesis that Se facilitates the biliary elimination of As, possibly via the putative formation of a Se-As conjugate using a glutathione complex. However, laboratory based studies are needed to provide further evidence to elucidate the presence of Se-As conjugate and its role in arsenic elimination in humans.
format Online
Article
Text
id pubmed-3724573
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-37245732013-07-27 A Cross-sectional Study of the Impact of Blood Selenium on Blood and Urinary Arsenic Concentrations in Bangladesh George, Christine Marie Gamble, Mary Slavkovich, Vesna Levy, Diane Ahmed, Alauddin Ahsan, Habibul Graziano, Joseph Environ Health Research BACKGROUND: Arsenic can naturally occur in the groundwater without an anthropogenic source of contamination. In Bangladesh over 50 million people are exposed to naturally occurring arsenic concentrations exceeding the World Health Organization’s guideline of 10 μg/L. Selenium and arsenic have been shown to facilitate the excretion of each other in bile. Recent evidence suggests that selenium may play a role in arsenic elimination by forming a selenium-arsenic conjugate in the liver before excretion into the bile. METHODS: A cross-sectional study of 1601 adults and 287 children was conducted to assess the relationship between blood selenium and urinary and blood arsenic in a study population residing in a moderately arsenic-contaminated rural area in Bangladesh. RESULTS: The results of this study indicate a statistically significant inverse relationship between blood selenium and urinary arsenic concentrations in both adult and pediatric populations in rural Bangladesh after adjustment for age, sex, Body Mass Index, plasma folate and B12 (in children), and ever smoking and current betel nut use (in adults). In addition, there appears to be a statistically significant inverse relationship between blood selenium and blood arsenic in children. CONCLUSIONS: Our results suggest that selenium is inversely associated with biomarkers of arsenic burden in both adults and children. These findings support the hypothesis that Se facilitates the biliary elimination of As, possibly via the putative formation of a Se-As conjugate using a glutathione complex. However, laboratory based studies are needed to provide further evidence to elucidate the presence of Se-As conjugate and its role in arsenic elimination in humans. BioMed Central 2013-07-01 /pmc/articles/PMC3724573/ /pubmed/23816141 http://dx.doi.org/10.1186/1476-069X-12-52 Text en Copyright © 2013 George et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
George, Christine Marie
Gamble, Mary
Slavkovich, Vesna
Levy, Diane
Ahmed, Alauddin
Ahsan, Habibul
Graziano, Joseph
A Cross-sectional Study of the Impact of Blood Selenium on Blood and Urinary Arsenic Concentrations in Bangladesh
title A Cross-sectional Study of the Impact of Blood Selenium on Blood and Urinary Arsenic Concentrations in Bangladesh
title_full A Cross-sectional Study of the Impact of Blood Selenium on Blood and Urinary Arsenic Concentrations in Bangladesh
title_fullStr A Cross-sectional Study of the Impact of Blood Selenium on Blood and Urinary Arsenic Concentrations in Bangladesh
title_full_unstemmed A Cross-sectional Study of the Impact of Blood Selenium on Blood and Urinary Arsenic Concentrations in Bangladesh
title_short A Cross-sectional Study of the Impact of Blood Selenium on Blood and Urinary Arsenic Concentrations in Bangladesh
title_sort cross-sectional study of the impact of blood selenium on blood and urinary arsenic concentrations in bangladesh
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724573/
https://www.ncbi.nlm.nih.gov/pubmed/23816141
http://dx.doi.org/10.1186/1476-069X-12-52
work_keys_str_mv AT georgechristinemarie acrosssectionalstudyoftheimpactofbloodseleniumonbloodandurinaryarsenicconcentrationsinbangladesh
AT gamblemary acrosssectionalstudyoftheimpactofbloodseleniumonbloodandurinaryarsenicconcentrationsinbangladesh
AT slavkovichvesna acrosssectionalstudyoftheimpactofbloodseleniumonbloodandurinaryarsenicconcentrationsinbangladesh
AT levydiane acrosssectionalstudyoftheimpactofbloodseleniumonbloodandurinaryarsenicconcentrationsinbangladesh
AT ahmedalauddin acrosssectionalstudyoftheimpactofbloodseleniumonbloodandurinaryarsenicconcentrationsinbangladesh
AT ahsanhabibul acrosssectionalstudyoftheimpactofbloodseleniumonbloodandurinaryarsenicconcentrationsinbangladesh
AT grazianojoseph acrosssectionalstudyoftheimpactofbloodseleniumonbloodandurinaryarsenicconcentrationsinbangladesh
AT georgechristinemarie crosssectionalstudyoftheimpactofbloodseleniumonbloodandurinaryarsenicconcentrationsinbangladesh
AT gamblemary crosssectionalstudyoftheimpactofbloodseleniumonbloodandurinaryarsenicconcentrationsinbangladesh
AT slavkovichvesna crosssectionalstudyoftheimpactofbloodseleniumonbloodandurinaryarsenicconcentrationsinbangladesh
AT levydiane crosssectionalstudyoftheimpactofbloodseleniumonbloodandurinaryarsenicconcentrationsinbangladesh
AT ahmedalauddin crosssectionalstudyoftheimpactofbloodseleniumonbloodandurinaryarsenicconcentrationsinbangladesh
AT ahsanhabibul crosssectionalstudyoftheimpactofbloodseleniumonbloodandurinaryarsenicconcentrationsinbangladesh
AT grazianojoseph crosssectionalstudyoftheimpactofbloodseleniumonbloodandurinaryarsenicconcentrationsinbangladesh