Cargando…

Reduction of microglial activity in a model of multiple sclerosis by dipyridamole

BACKGROUND: Despite extensive and persistent activation of microglia in multiple sclerosis (MS), microglia inhibitors have not yet been identified for treatment of the disorder. We sought to identify medications already in clinical use that could inhibit the activation of microglia. On the basis of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sloka, Scott, Metz, Luanne M, Hader, Walter, Starreveld, Yves, Yong, V Wee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724584/ https://www.ncbi.nlm.nih.gov/pubmed/23866809 http://dx.doi.org/10.1186/1742-2094-10-89

Ejemplares similares

1,25-Dihydroxyvitamin D(3) Protects against Immune-Mediated Killing of Neurons in Culture and in Experimental Autoimmune Encephalomyelitis
por: Sloka, Scott, et al.
Publicado: (2015)

Environmental factors and their regulation of immunity in multiple sclerosis
por: Koch, Marcus W., et al.
Publicado: (2013)

Focus on the gut-brain axis: Multiple sclerosis, the intestinal barrier and the microbiome
por: Camara-Lemarroy, Carlos R, et al.
Publicado: (2018)

Prolactin in combination with interferon-β reduces disease severity in an animal model of multiple sclerosis
por: Zhornitsky, Simon, et al.
Publicado: (2015)

Expanding the Potential Therapeutic Options for Remote Ischemic Preconditioning: Use in Multiple Sclerosis
por: Camara-Lemarroy, Carlos R., et al.
Publicado: (2018)

Laquinimod reduces neuroaxonal injury through inhibiting microglial activation
por: Mishra, Manoj Kumar, et al.
Publicado: (2014)

Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic
por: Faissner, Simon, et al.
Publicado: (2017)

Distinct characteristics and severity of brain magnetic resonance imaging lesions in women and men with multiple sclerosis assessed using verified texture analysis measures
por: Hosseinpour, Zahra, et al.
Publicado: (2023)

Discriminative ability of quality of life measures in multiple sclerosis
por: Fiest, Kirsten M., et al.
Publicado: (2017)

Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons
por: Singh, Shailender, et al.
Publicado: (2013)

The Prevalence of Familial Multiple Sclerosis in Saskatoon, Saskatchewan
por: Hader, Walter J., et al.
Publicado: (2014)

Dipyridamole ameliorates doxorubicin-induced cardiotoxicity
por: Alyasiry, Esraa, et al.
Publicado: (2022)

Models of Care in Multiple Sclerosis: A Survey of Canadian Health Providers
por: Marrie, Ruth Ann, et al.
Publicado: (2022)

Co-occurrence of autoimmune thyroid disease in a multiple sclerosis cohort
por: Sloka, JS, et al.
Publicado: (2005)

The Canadian prospective cohort study to understand progression in multiple sclerosis (CanProCo): rationale, aims, and study design
por: Oh, Jiwon, et al.
Publicado: (2021)

Microglial Phagocytosis—Rational but Challenging Therapeutic Target in Multiple Sclerosis
por: Pinto, Maria V., et al.
Publicado: (2020)

Association of serum neurofilament light with microglial activation in multiple sclerosis
por: Saraste, Maija, et al.
Publicado: (2023)

Dipyridamole and vascular healing following stent implantation
por: Simard, Trevor, et al.
Publicado: (2023)

Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis
por: McKenzie, Brienne A., et al.
Publicado: (2020)

Predominance of Th2 polarization by Vitamin D through a STAT6-dependent mechanism
por: Sloka, Scott, et al.
Publicado: (2011)

The Benefits and Detriments of Macrophages/Microglia in Models of Multiple Sclerosis
por: Rawji, Khalil S., et al.
Publicado: (2013)

Microglial Pruning: Relevance for Synaptic Dysfunction in Multiple Sclerosis and Related Experimental Models
por: Geloso, Maria Concetta, et al.
Publicado: (2021)

Characterizing microglial gene expression in a model of secondary progressive multiple sclerosis
por: Vainchtein, Ilia D., et al.
Publicado: (2022)

Dipyridamole augments the antiinflammatory response during human endotoxemia
por: Ramakers, Bart P, et al.
Publicado: (2011)

The signal pathway for the repressive effect of dipyridamole on myofibroblast transdifferentiation
por: Yan, Qiong, et al.
Publicado: (2018)

Dipyridamole-induced STEMI: case report and review of the literature
por: Hennawi, Hussam Al, et al.
Publicado: (2023)

Accounting for uncertainty in training data to improve machine learning performance in predicting new disease activity in early multiple sclerosis
por: Tayyab, Maryam, et al.
Publicado: (2023)

Advanced Analysis of Diffusion Tensor Imaging Along With Machine Learning Provides New Sensitive Measures of Tissue Pathology and Intra-Lesion Activity in Multiple Sclerosis
por: Oladosu, Olayinka, et al.
Publicado: (2021)

Evaluation of Microglial Activation in Multiple Sclerosis Patients Using Positron Emission Tomography
por: Airas, Laura, et al.
Publicado: (2018)

Dipyridamole modulates the innate immune response during human endotoxemia
por: Ramakers, B, et al.
Publicado: (2011)

Ocular Applications of Dipyridamole: A Review of Indications and Routes of Administration
por: Rogosnitzky, Moshe, et al.
Publicado: (2016)

The possible protective effects of dipyridamole on ischemic reperfusion injury of priapism
por: Karaguzel, Ersagun, et al.
Publicado: (2016)

Assessment of dipyridamole stress echocardiography for risk stratification of diabetic patients
por: Baroncini, Liz Andréa Villela, et al.
Publicado: (2015)

Unusual Dipyridamole-induced Aberrant Conduction in the Absence of Myocardial Ischemia
por: Ricca-Mallada, Roberto, et al.
Publicado: (2017)

Dipyridamole induces the phosphorylation of CREB to promote cancer cell proliferation
por: Abdelghany, Lina, et al.
Publicado: (2021)

Atrioventricular (AV) block and sinus arrest associated with dipyridamole infusion
por: Khalili, Mahdi, et al.
Publicado: (2022)

Advanced diffusion MRI and image texture analysis detect widespread brain structural differences between relapsing-remitting and secondary progressive multiple sclerosis
por: Oladosu, Olayinka, et al.
Publicado: (2022)

Dipyridamole reduces penile apoptosis in a rat model of post-prostatectomy erectile dysfunction
por: Kutlu, Omer, et al.
Publicado: (2017)

Dipyridamole potentiates the in vitro activity of MTA (LY231514) by inhibition of thymidine transport
por: Smith, P G, et al.
Publicado: (2000)

Expression of risk genes linked to vitamin D receptor super-enhancer regions and their association with phenotype severity in multiple sclerosis
por: Orton, Sarah M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_54eb89o748flrsj663ugsno25m