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Clinically Relevant Dimer Interface Mutants of STAT1 Transcription Factor Exhibit Differential Gene Expression

A transition from a parallel to an antiparallel dimer configuration of the transcription factor signal transducer and activator of transcription 1 (STAT1) is required for interferon (IFN)-mediated signal transduction. However, the precise molecular mechanisms linking conformational changes to target...

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Detalles Bibliográficos
Autores principales:	Staab, Julia, Herrmann-Lingen, Christoph, Meyer, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724676/ https://www.ncbi.nlm.nih.gov/pubmed/23922848 http://dx.doi.org/10.1371/journal.pone.0069903

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