The Pathological Phenotypes of Human TDP-43 Transgenic Mouse Models Are Independent of Downregulation of Mouse Tdp-43

Tar DNA binding protein 43 (TDP-43) is the major component of pathological deposits in frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) and in amyotrophic lateral sclerosis (ALS). It has been reported that TDP-43 transgenic mouse models expressing human TDP-43 wild-type or ALS-ass...

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Detalles Bibliográficos
Autores principales: Xu, Ya-Fei, Prudencio, Mercedes, Hubbard, Jaime M., Tong, Jimei, Whitelaw, Ena C., Jansen-West, Karen, Stetler, Caroline, Cao, Xiangkun, Song, John, Zhang, Yong-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724736/
https://www.ncbi.nlm.nih.gov/pubmed/23922830
http://dx.doi.org/10.1371/journal.pone.0069864

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