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Tyrosine 416 Is Phosphorylated in the Closed, Repressed Conformation of c-Src

c-Src kinase activity is regulated by phosphorylation of Y527 and Y416. Y527 phosphorylation stabilizes a closed conformation, which suppresses kinase activity towards substrates, whereas phosphorylation at Y416 promotes an elevated kinase activity by stabilizing the activation loop in a manner perm...

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Detalles Bibliográficos
Autores principales:	Irtegun, Sevgi, Wood, Rebecca J., Ormsby, Angelique R., Mulhern, Terrence D., Hatters, Danny M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724807/ https://www.ncbi.nlm.nih.gov/pubmed/23923048 http://dx.doi.org/10.1371/journal.pone.0071035

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