Cargando…

Tyrosine 416 Is Phosphorylated in the Closed, Repressed Conformation of c-Src

c-Src kinase activity is regulated by phosphorylation of Y527 and Y416. Y527 phosphorylation stabilizes a closed conformation, which suppresses kinase activity towards substrates, whereas phosphorylation at Y416 promotes an elevated kinase activity by stabilizing the activation loop in a manner perm...

Descripción completa

Detalles Bibliográficos
Autores principales:	Irtegun, Sevgi, Wood, Rebecca J., Ormsby, Angelique R., Mulhern, Terrence D., Hatters, Danny M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724807/ https://www.ncbi.nlm.nih.gov/pubmed/23923048 http://dx.doi.org/10.1371/journal.pone.0071035

Ejemplares similares

Protein painting reveals pervasive remodeling of conserved proteostasis machinery in response to pharmacological stimuli
por: Cox, Dezerae, et al.
Publicado: (2022)

c‐Cbl Is Inducibly Tyrosine‐phosphorylated by Epidermal Growth Factor Stimulation in Fibroblasts, and Constitutively Tyrosine‐phosphorylated and Associated with v‐Src in v‐src‐transformed Fibroblasts
por: Odai, Hideharu, et al.
Publicado: (1995)

Cbl-associated protein is tyrosine phosphorylated by c-Abl and c-Src kinases
por: Fernow, Inga, et al.
Publicado: (2009)

Flipping the switch: How cysteine oxidation directs tau amyloid conformations
por: Hatters, Danny M.
Publicado: (2021)

Redox Regulation of NOX Isoforms on FAK((Y397))/SRC((Y416)) Phosphorylation Driven Epithelial-to-Mesenchymal Transition in Malignant Cervical Epithelial Cells
por: Kim, Young Mee, et al.
Publicado: (2020)

Tyrosine Phosphorylation of Tau by the Src Family Kinases Lck and Fyn
por: Scales, Timothy ME, et al.
Publicado: (2011)

Pharmacological Inactivation of Src Family Kinases Inhibits LPS-Induced TNF-α Production in PBMC of Patients with Behçet's Disease
por: Irtegun, Sevgi, et al.
Publicado: (2016)

A Src-Like Inactive Conformation in the Abl Tyrosine Kinase Domain
por: Levinson, Nicholas M, et al.
Publicado: (2006)

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA
por: Ormsby, Angelique R., et al.
Publicado: (2020)

Computational Study of the “DFG-Flip” Conformational Transition in c-Abl and c-Src Tyrosine Kinases
por: Meng, Yilin, et al.
Publicado: (2014)

A Platform to View Huntingtin Exon 1 Aggregation Flux in the Cell Reveals Divergent Influences from Chaperones hsp40 and hsp70
por: Ormsby, Angelique R., et al.
Publicado: (2013)

Tubulin is phosphorylated at tyrosine by pp60c-src in nerve growth cone membranes
Publicado: (1990)

Network approach of the conformational change of c-Src, a tyrosine kinase, by molecular dynamics simulation
por: Yoon, Hyun Jung, et al.
Publicado: (2018)

Arginine in C9ORF72 Dipolypeptides Mediates Promiscuous Proteome Binding and Multiple Modes of Toxicity
por: Radwan, Mona, et al.
Publicado: (2020)

Tyrosine Phosphorylation and Src Family Kinases Control Keratinocyte Cell–Cell Adhesion
por: Calautti, Enzo, et al.
Publicado: (1998)

Src Kinase Phosphorylates RUNX3 at Tyrosine Residues and Localizes the Protein in the Cytoplasm
por: Goh, Yun-Mi, et al.
Publicado: (2010)

Tyrosine phosphorylation of lamin A by Src promotes disassembly of nuclear lamina in interphase
por: Chu, Ching-Tung, et al.
Publicado: (2021)

Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle
por: Morii, Mariko, et al.
Publicado: (2021)

Src-Dependent NM2A Tyrosine Phosphorylation Regulates Actomyosin Remodeling
por: Brito, Cláudia, et al.
Publicado: (2023)

Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src
por: Tsang, Jennifer LY, et al.
Publicado: (2016)

The R416 Cerenkov counters
por: Meyer, W T
Publicado: (1980)

Drosophila Kelch regulates actin organization via Src64-dependent tyrosine phosphorylation
por: Kelso, Reed J., et al.
Publicado: (2002)

Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility
por: Wang, Wenqi, et al.
Publicado: (2011)

Endocytosis of somatodendritic NCKX2 is regulated by Src family kinase-dependent tyrosine phosphorylation
por: Lee, Kyu-Hee, et al.
Publicado: (2013)

Siglec-6 Signaling Uses Src Kinase Tyrosine Phosphorylation and SHP-2 Recruitment
por: Stefanski, Adrianne L., et al.
Publicado: (2022)

c-Src kinase is involved in the tyrosine phosphorylation and activity of SLC11A1 in differentiating macrophages
por: Xu, Yong Zhong, et al.
Publicado: (2018)

Extracellular Phosphorylation of TIMP-2 by Secreted c-Src Tyrosine Kinase Controls MMP-2 Activity
por: Sánchez-Pozo, Javier, et al.
Publicado: (2018)

A biosensor-based framework to measure latent proteostasis capacity
por: Wood, Rebecca J., et al.
Publicado: (2018)

Status report on experiment R416
por: Burlaud, P, et al.
Publicado: (1978)

FRI416 Primary Hyperaldosteronism in Pregnancy
por: Seav, Susan M, et al.
Publicado: (2023)

Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts
Publicado: (1992)

Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases
por: Liu, Yuanbo, et al.
Publicado: (2010)

eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin
por: Ninchoji, Takeshi, et al.
Publicado: (2021)

SHP-1 tyrosine phosphatase binding to c-Src kinase phosphor-dependent conformations: A comparative structural framework
por: Gul, Mehreen, et al.
Publicado: (2023)

Status report about experiment R416
por: Frehse, H
Publicado: (1979)

SUN-416 Ipilimumab Associated Hypophysitis and Thyroiditis
por: Kazi, Fatima, et al.
Publicado: (2019)

Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated
Publicado: (1991)

Nuclear Functions of the Tyrosine Kinase Src
por: Bagnato, Giulia, et al.
Publicado: (2020)

Src tyrosine kinase augments taxotere-induced apoptosis through enhanced expression and phosphorylation of Bcl-2
por: Boudny, V, et al.
Publicado: (2002)

Tyrosine phosphorylation of type Iγ phosphatidylinositol phosphate kinase by Src regulates an integrin–talin switch
por: Ling, Kun, et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_9a9losst5u8m835ac945t16erc