MicroRNA-1 Downregulation Increases Connexin 43 Displacement and Induces Ventricular Tachyarrhythmias in Rodent Hypertrophic Hearts

Downregulation of the muscle-specific microRNA-1 (miR-1) mediates the induction of pathologic cardiac hypertrophy. Dysfunction of the gap junction protein connexin 43 (Cx43), an established miR-1 target, during cardiac hypertrophy leads to ventricular tachyarrhythmias (VT). However, it is still unkn...

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Detalles Bibliográficos
Autores principales: Curcio, Antonio, Torella, Daniele, Iaconetti, Claudio, Pasceri, Eugenia, Sabatino, Jolanda, Sorrentino, Sabato, Giampà, Salvatore, Micieli, Mariella, Polimeni, Alberto, Henning, Beverley J., Leone, Angelo, Catalucci, Daniele, Ellison, Georgina M., Condorelli, Gianluigi, Indolfi, Ciro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724819/
https://www.ncbi.nlm.nih.gov/pubmed/23922949
http://dx.doi.org/10.1371/journal.pone.0070158

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