Cargando…

Resuscitation of Ischemic Donor Livers with Normothermic Machine Perfusion: A Metabolic Flux Analysis of Treatment in Rats

Normothermic machine perfusion has previously been demonstrated to restore damaged warm ischemic livers to transplantable condition in animal models. However, the mechanisms of recovery are unclear, preventing rational optimization of perfusion systems and slowing clinical translation of machine per...

Descripción completa

Detalles Bibliográficos
Autores principales:	Izamis, Maria-Louisa, Tolboom, Herman, Uygun, Basak, Berthiaume, Francois, Yarmush, Martin L., Uygun, Korkut
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724866/ https://www.ncbi.nlm.nih.gov/pubmed/23922793 http://dx.doi.org/10.1371/journal.pone.0069758

Ejemplares similares

A Metabolic Index of Ischemic Injury for Perfusion-Recovery of Cadaveric Rat Livers
por: Perk, Sinem, et al.
Publicado: (2011)

A fitness index for transplantation of machine-perfused cadaveric rat livers
por: Perk, Sinem, et al.
Publicado: (2012)

Development of Metabolic Indicators of Burn Injury: Very Low Density Lipoprotein (VLDL) and Acetoacetate Are Highly Correlated to Severity of Burn Injury in Rats
por: Izamis, Maria-Louisa, et al.
Publicado: (2012)

A simplified subnormothermic machine perfusion system restores ischemically damaged liver grafts in a rat model of orthotopic liver transplantation
por: Berendsen, Tim A, et al.
Publicado: (2012)

Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies
por: Raigani, Siavash, et al.
Publicado: (2020)

Subnormothermic Machine Perfusion of Steatotic Livers Results in Increased Energy Charge at the Cost of Anti-Oxidant Capacity Compared to Normothermic Perfusion
por: Karimian, Negin, et al.
Publicado: (2019)

Improvement of steatotic rat liver function with a defatting cocktail during ex situ normothermic machine perfusion is not directly related to liver fat content
por: Raigani, Siavash, et al.
Publicado: (2020)

Successful Supercooled Liver Storage for 4 Days
por: Berendsen, Tim A., et al.
Publicado: (2014)

Thrombolytic Therapy During ex-vivo Normothermic Machine Perfusion of Human Livers Reduces Peribiliary Vascular Plexus Injury
por: Haque, Omar, et al.
Publicado: (2021)

The effect of blood cells retained in rat livers during static cold storage on viability outcomes during normothermic machine perfusion
por: Haque, Omar, et al.
Publicado: (2021)

Supercooling as a Viable Non-Freezing Cell Preservation Method of Rat Hepatocytes
por: Usta, O. Berk, et al.
Publicado: (2013)

121. Acellular Subnomothermic Machine Perfusion of Fasciocutaneous Flaps in Swine
por: Berkane, Yanis, et al.
Publicado: (2023)

Pan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates ex situ innate immune responses
por: Raigani, Siavash, et al.
Publicado: (2022)

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
por: Bruinsma, Bote G., et al.
Publicado: (2015)

The Effect of Normothermic Machine Perfusion on the Immune Profile of Donor Liver
por: Lee, Andy Chao Hsuan, et al.
Publicado: (2022)

Metabolomic Modularity Analysis (MMA) to Quantify Human Liver Perfusion Dynamics
por: Sridharan, Gautham Vivek, et al.
Publicado: (2017)

Normothermic machine perfusion of donor livers without the need for human blood products
por: Matton, Alix P. M., et al.
Publicado: (2018)

Tryptophan Metabolism via the Kynurenine Pathway: Implications for Graft Optimization during Machine Perfusion
por: Zhang, Anna, et al.
Publicado: (2020)

Endothelial Dysfunction in Steatotic Human Donor Livers: A Pilot Study of the Underlying Mechanism During Subnormothermic Machine Perfusion
por: Beijert, Irene, et al.
Publicado: (2018)

Normothermic Machine Perfusion of Deceased Donor Liver Grafts Is Associated With Improved Postreperfusion Hemodynamics
por: Angelico, Roberta, et al.
Publicado: (2016)

Understanding the Immunology of Normothermic Machine Perfusion
por: Clatworthy, Menna Ruth, et al.
Publicado: (2023)

Anti-apoptotic treatment of warm ischemic male rat livers in machine perfusion improves symptoms of ischemia-reperfusion injury
por: Mojoudi, Mohammadreza, et al.
Publicado: (2023)

Combined Hypothermic and Normothermic Machine Perfusion Improves Functional Recovery of Extended Criteria Donor Livers
por: Boteon, Yuri L., et al.
Publicado: (2018)

Transplantation of Extended Criteria Donor Livers Following Continuous Normothermic Machine Perfusion Without Recooling
por: Chen, Zhitao, et al.
Publicado: (2022)

Sequential hypothermic and normothermic machine perfusion enables safe transplantation of high‐risk donor livers
por: van Leeuwen, Otto B., et al.
Publicado: (2022)

Restoration of Bile Duct Injury of Donor Livers During Ex Situ Normothermic Machine Perfusion
por: de Jong, Iris E.M., et al.
Publicado: (2023)

Successful Transplantation of Human Kidneys Deemed Untransplantable but Resuscitated by Ex Vivo Normothermic Machine Perfusion
por: Hosgood, S. A., et al.
Publicado: (2016)

Improved Normothermic Machine Perfusion After Short Oxygenated Hypothermic Machine Perfusion of Ischemically Injured Porcine Kidneys
por: Lignell, Stina, et al.
Publicado: (2021)

Image-guided sonoporation in an ex vivo machine perfused porcine liver
por: Keravnou, Christina, et al.
Publicado: (2015)

Viability assessment and transplantation of fatty liver grafts using end‐ischemic normothermic machine perfusion
por: Patrono, Damiano, et al.
Publicado: (2023)

Criteria for Viability Assessment of Discarded Human Donor Livers during Ex Vivo Normothermic Machine Perfusion
por: Sutton, Michael E., et al.
Publicado: (2014)

In situ normothermic regional perfusion versus ex situ normothermic machine perfusion in liver transplantation from donation after circulatory death
por: Mohkam, Kayvan, et al.
Publicado: (2022)

Proof of concept: liver splitting during normothermic machine perfusion
por: Stephenson, Barney T F, et al.
Publicado: (2018)

Methaemoglobinaemia Can Complicate Normothermic Machine Perfusion of Human Livers
por: Tingle, Samuel J., et al.
Publicado: (2021)

The Distinct Innate Immune Response of Warm Ischemic Injured Livers during Continuous Normothermic Machine Perfusion
por: Blondeel, Joris, et al.
Publicado: (2023)

Safety and feasibility of 2 h of normothermic machine perfusion of donor kidneys in the Eurotransplant Senior Program
por: Rijkse, E, et al.
Publicado: (2021)

Optimizing porcine donor kidney preservation with normothermic or hypothermic machine perfusion: A systematic review
por: Bouari, Sarah, et al.
Publicado: (2021)

Extracellular Vesicles Released During Normothermic Machine Perfusion Are Associated With Human Donor Kidney Characteristics
por: Woud, Wouter W., et al.
Publicado: (2022)

Manipulation of Lipid Metabolism During Normothermic Machine Perfusion: Effect of Defatting Therapies on Donor Liver Functional Recovery
por: Boteon, Yuri L., et al.
Publicado: (2019)

The Delivery of Multipotent Adult Progenitor Cells to Extended Criteria Human Donor Livers Using Normothermic Machine Perfusion
por: Laing, Richard W., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_a8n26pd836gmtgkb40cfcdouk0