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Boolean Network Model for Cancer Pathways: Predicting Carcinogenesis and Targeted Therapy Outcomes
A Boolean dynamical system integrating the main signaling pathways involved in cancer is constructed based on the currently known protein-protein interaction network. This system exhibits stationary protein activation patterns – attractors – dependent on the cell's microenvironment. These dynam...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724878/ https://www.ncbi.nlm.nih.gov/pubmed/23922675 http://dx.doi.org/10.1371/journal.pone.0069008 |