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Genetic Variation in the NOC Gene Is Associated with Body Mass Index in Chinese Subjects
Circadian clock genes are critical regulators of energy homeostasis and metabolism. However, whether variation in the circadian genes is associated with metabolic phenotypes in humans remains to be explored. In this study, we systemically genotyped 20 tag single nucleotide polymorphisms (SNPs) in 8...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724939/ https://www.ncbi.nlm.nih.gov/pubmed/23922759 http://dx.doi.org/10.1371/journal.pone.0069622 |
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author | Chang, Yi-Cheng Chiu, Yen-Feng Liu, Pi-Hua Hee, Siow Wei Chang, Tien-Jyun Jiang, Yi-Der Lee, Wei-Jei Lee, Po-Chu Kao, Hui-Yi Hwang, Juey-Jen Chuang, Lee-Ming |
author_facet | Chang, Yi-Cheng Chiu, Yen-Feng Liu, Pi-Hua Hee, Siow Wei Chang, Tien-Jyun Jiang, Yi-Der Lee, Wei-Jei Lee, Po-Chu Kao, Hui-Yi Hwang, Juey-Jen Chuang, Lee-Ming |
author_sort | Chang, Yi-Cheng |
collection | PubMed |
description | Circadian clock genes are critical regulators of energy homeostasis and metabolism. However, whether variation in the circadian genes is associated with metabolic phenotypes in humans remains to be explored. In this study, we systemically genotyped 20 tag single nucleotide polymorphisms (SNPs) in 8 candidate genes involved in circadian clock, including CLOCK, BMAL1(ARNTL), PER1, PER2, CRY1, CRY2, CSNK1E,, and NOC(CCRN4L) in 1,510 non-diabetic Chinese subjects in Taipei and Yunlin populations in Taiwan. Their associations with metabolic phenotypes were analyzed. We found that genetic variation in the NOC gene, rs9684900 was associated with body mass index (BMI) (P = 0.0016, Bonferroni corrected P = 0.032). Another variant, rs135764 in the CSNK1E gene was associated with fasting glucose (P = 0.0023, Bonferroni corrected P = 0.046). These associations were consistent in both Taipei and Yunlin populations. Significant epistatic and joint effects between SNPs on BMI and related phenotypes were observed. Furthermore, NOC mRNA levels in human abdominal adipose tissue were significantly increased in obese subjects compared to non-obese controls. CONCLUSION: Genetic variation in the NOC gene is associated with BMI in Chinese subjects. |
format | Online Article Text |
id | pubmed-3724939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37249392013-08-06 Genetic Variation in the NOC Gene Is Associated with Body Mass Index in Chinese Subjects Chang, Yi-Cheng Chiu, Yen-Feng Liu, Pi-Hua Hee, Siow Wei Chang, Tien-Jyun Jiang, Yi-Der Lee, Wei-Jei Lee, Po-Chu Kao, Hui-Yi Hwang, Juey-Jen Chuang, Lee-Ming PLoS One Research Article Circadian clock genes are critical regulators of energy homeostasis and metabolism. However, whether variation in the circadian genes is associated with metabolic phenotypes in humans remains to be explored. In this study, we systemically genotyped 20 tag single nucleotide polymorphisms (SNPs) in 8 candidate genes involved in circadian clock, including CLOCK, BMAL1(ARNTL), PER1, PER2, CRY1, CRY2, CSNK1E,, and NOC(CCRN4L) in 1,510 non-diabetic Chinese subjects in Taipei and Yunlin populations in Taiwan. Their associations with metabolic phenotypes were analyzed. We found that genetic variation in the NOC gene, rs9684900 was associated with body mass index (BMI) (P = 0.0016, Bonferroni corrected P = 0.032). Another variant, rs135764 in the CSNK1E gene was associated with fasting glucose (P = 0.0023, Bonferroni corrected P = 0.046). These associations were consistent in both Taipei and Yunlin populations. Significant epistatic and joint effects between SNPs on BMI and related phenotypes were observed. Furthermore, NOC mRNA levels in human abdominal adipose tissue were significantly increased in obese subjects compared to non-obese controls. CONCLUSION: Genetic variation in the NOC gene is associated with BMI in Chinese subjects. Public Library of Science 2013-07-26 /pmc/articles/PMC3724939/ /pubmed/23922759 http://dx.doi.org/10.1371/journal.pone.0069622 Text en © 2013 Chang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Chang, Yi-Cheng Chiu, Yen-Feng Liu, Pi-Hua Hee, Siow Wei Chang, Tien-Jyun Jiang, Yi-Der Lee, Wei-Jei Lee, Po-Chu Kao, Hui-Yi Hwang, Juey-Jen Chuang, Lee-Ming Genetic Variation in the NOC Gene Is Associated with Body Mass Index in Chinese Subjects |
title | Genetic Variation in the NOC Gene Is Associated with Body Mass Index in Chinese Subjects |
title_full | Genetic Variation in the NOC Gene Is Associated with Body Mass Index in Chinese Subjects |
title_fullStr | Genetic Variation in the NOC Gene Is Associated with Body Mass Index in Chinese Subjects |
title_full_unstemmed | Genetic Variation in the NOC Gene Is Associated with Body Mass Index in Chinese Subjects |
title_short | Genetic Variation in the NOC Gene Is Associated with Body Mass Index in Chinese Subjects |
title_sort | genetic variation in the noc gene is associated with body mass index in chinese subjects |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724939/ https://www.ncbi.nlm.nih.gov/pubmed/23922759 http://dx.doi.org/10.1371/journal.pone.0069622 |
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