Filgrastim therapy in a child with neutropenia induced by linezolid

We describe the case of a young child with multidrug-resistant tuberculosis, treated with linezolid. The child developed severe neutropenia after 5 months of treatment. Filgrastim was used, a drug that officially is not indicated for non-cytostatic drug-induced neutropenia. This allowed the fast rec...

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Detalles Bibliográficos
Autores principales: Hernández Segurado, Marta, Arias Moya, Maria Ángeles, Gómez Pérez, Marta, Bonilla Porras, Macarena, Castillo Bazán, Eva, Bécares Martínez, Francisco Javier, Toledano Mayoral, Gema, Panadero Esteban, María Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724981/
https://www.ncbi.nlm.nih.gov/pubmed/23820894
http://dx.doi.org/10.1007/s11096-013-9814-8
Descripción
Sumario:We describe the case of a young child with multidrug-resistant tuberculosis, treated with linezolid. The child developed severe neutropenia after 5 months of treatment. Filgrastim was used, a drug that officially is not indicated for non-cytostatic drug-induced neutropenia. This allowed the fast recovery of the patient’s neutrophil-count. However, more experience with the off-label use of filgrastrim is needed in the pediatric population.

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